Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time

Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notification was as...

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Detalles Bibliográficos
Autores principales: Ly, Tam, Gulia, Jyoti, Pyrgos, Vasilios, Waga, Masashi, Shoham, Shmuel
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500257/
https://www.ncbi.nlm.nih.gov/pubmed/18827860
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author Ly, Tam
Gulia, Jyoti
Pyrgos, Vasilios
Waga, Masashi
Shoham, Shmuel
author_facet Ly, Tam
Gulia, Jyoti
Pyrgos, Vasilios
Waga, Masashi
Shoham, Shmuel
author_sort Ly, Tam
collection PubMed
description Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notification was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges.
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spelling pubmed-25002572008-10-01 Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time Ly, Tam Gulia, Jyoti Pyrgos, Vasilios Waga, Masashi Shoham, Shmuel Ther Clin Risk Manag Original Research Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notification was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2500257/ /pubmed/18827860 Text en © 2008 Ly et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Original Research
Ly, Tam
Gulia, Jyoti
Pyrgos, Vasilios
Waga, Masashi
Shoham, Shmuel
Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title_full Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title_fullStr Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title_full_unstemmed Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title_short Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time
title_sort impact upon clinical outcomes of translation of pna fish-generated laboratory data from the clinical microbiology bench to bedside in real time
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500257/
https://www.ncbi.nlm.nih.gov/pubmed/18827860
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