Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome

Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well tolerated, rare serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulapathies, bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerstner, Thorsten, Bell, Nellie, Koenig, Stephan A
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500259/
https://www.ncbi.nlm.nih.gov/pubmed/18827862
_version_ 1782158326877913088
author Gerstner, Thorsten
Bell, Nellie
Koenig, Stephan A
author_facet Gerstner, Thorsten
Bell, Nellie
Koenig, Stephan A
author_sort Gerstner, Thorsten
collection PubMed
description Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well tolerated, rare serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulapathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy. We report a case of VPA-associated encephalopathy without hyperammonemia in a 3-year-old girl with Pallister-Killian-Syndrom, combined with a mild hepatopathy and thrombopathy. After withdrawal of VPA, the clinical symptoms and the electroencephalography-alterations vanished rapidly.
format Text
id pubmed-2500259
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-25002592008-10-01 Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome Gerstner, Thorsten Bell, Nellie Koenig, Stephan A Ther Clin Risk Manag Case Report Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well tolerated, rare serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulapathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy. We report a case of VPA-associated encephalopathy without hyperammonemia in a 3-year-old girl with Pallister-Killian-Syndrom, combined with a mild hepatopathy and thrombopathy. After withdrawal of VPA, the clinical symptoms and the electroencephalography-alterations vanished rapidly. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2500259/ /pubmed/18827862 Text en © 2008 Gerstner et al, publisher and licensee Dove Medical Press Ltd
spellingShingle Case Report
Gerstner, Thorsten
Bell, Nellie
Koenig, Stephan A
Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title_full Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title_fullStr Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title_full_unstemmed Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title_short Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
title_sort valproate-associated reversible encephalopathy in a 3-year-old girl with pallister-killian syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500259/
https://www.ncbi.nlm.nih.gov/pubmed/18827862
work_keys_str_mv AT gerstnerthorsten valproateassociatedreversibleencephalopathyina3yearoldgirlwithpallisterkilliansyndrome
AT bellnellie valproateassociatedreversibleencephalopathyina3yearoldgirlwithpallisterkilliansyndrome
AT koenigstephana valproateassociatedreversibleencephalopathyina3yearoldgirlwithpallisterkilliansyndrome

Ejemplares similares