Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms

Gene targeting via homologous recombination (HR) is an important application in biotechnology and medicine. However, in mammalian cells HR is much less efficient than random integration. Triplex-forming oligonucleotides (TFOs) linked to DNA damaging agents (e.g. psoralen) can stimulate HR, providing...

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Detalles Bibliográficos
Autores principales: Liu, Yaobin, Nairn, Rodney S., Vasquez, Karen M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504320/
https://www.ncbi.nlm.nih.gov/pubmed/18628293
http://dx.doi.org/10.1093/nar/gkn438

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