Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final m...

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Detalles Bibliográficos
Autores principales: Bugni, Tim S., Harper, Mary Kay, McCulloch, Malcolm W.B., Reppart, Jason, Ireland, Chris M.
Formato: Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505051/
https://www.ncbi.nlm.nih.gov/pubmed/18596663
http://dx.doi.org/10.3390/molecules13061372
Descripción
Sumario:The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.

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