Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final m...

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Detalles Bibliográficos
Autores principales: Bugni, Tim S., Harper, Mary Kay, McCulloch, Malcolm W.B., Reppart, Jason, Ireland, Chris M.
Formato: Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505051/
https://www.ncbi.nlm.nih.gov/pubmed/18596663
http://dx.doi.org/10.3390/molecules13061372
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author Bugni, Tim S.
Harper, Mary Kay
McCulloch, Malcolm W.B.
Reppart, Jason
Ireland, Chris M.
author_facet Bugni, Tim S.
Harper, Mary Kay
McCulloch, Malcolm W.B.
Reppart, Jason
Ireland, Chris M.
author_sort Bugni, Tim S.
collection PubMed
description The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.
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spelling pubmed-25050512008-08-11 Fractionated Marine Invertebrate Extract Libraries for Drug Discovery Bugni, Tim S. Harper, Mary Kay McCulloch, Malcolm W.B. Reppart, Jason Ireland, Chris M. Molecules Article The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented. MDPI 2008-06-19 /pmc/articles/PMC2505051/ /pubmed/18596663 http://dx.doi.org/10.3390/molecules13061372 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bugni, Tim S.
Harper, Mary Kay
McCulloch, Malcolm W.B.
Reppart, Jason
Ireland, Chris M.
Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_full Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_fullStr Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_full_unstemmed Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_short Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
title_sort fractionated marine invertebrate extract libraries for drug discovery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505051/
https://www.ncbi.nlm.nih.gov/pubmed/18596663
http://dx.doi.org/10.3390/molecules13061372
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AT irelandchrism fractionatedmarineinvertebrateextractlibrariesfordrugdiscovery

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