The frequency of CD127(low )expressing CD4(+)CD25(high )T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis

BACKGROUND: CD4(+)CD25(high )regulatory T (T(Reg)) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the function of T(Reg )cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. The purpose of th...

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Detalles Bibliográficos
Autores principales: Michaëlsson, Jakob, Barbosa, Hugo Marcelo R, Jordan, Kimberley A, Chapman, Joan M, Brunialti, Milena KC, Neto, Walter Kleine, Nukui, Youko, Sabino, Ester C, Chieia, Marco Antonio, Oliveira, Acary Souza Bulle, Nixon, Douglas F, Kallas, Esper G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515103/
https://www.ncbi.nlm.nih.gov/pubmed/18664281
http://dx.doi.org/10.1186/1471-2172-9-41

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