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The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case

BACKGROUND: With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly. CASE PRESENTATION: This paper describes a fast growing adenocarcinoma (NOS), originating from the minor saliv...

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Autores principales: Ettl, Tobias, Kleinheinz, Johannes, Mehrotra, Ravi, Schwarz, Stephan, Reichert, Torsten Eugen, Driemel, Oliver
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515301/
https://www.ncbi.nlm.nih.gov/pubmed/18667060
http://dx.doi.org/10.1186/1746-160X-4-16
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author Ettl, Tobias
Kleinheinz, Johannes
Mehrotra, Ravi
Schwarz, Stephan
Reichert, Torsten Eugen
Driemel, Oliver
author_facet Ettl, Tobias
Kleinheinz, Johannes
Mehrotra, Ravi
Schwarz, Stephan
Reichert, Torsten Eugen
Driemel, Oliver
author_sort Ettl, Tobias
collection PubMed
description BACKGROUND: With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly. CASE PRESENTATION: This paper describes a fast growing adenocarcinoma (NOS), originating from the minor salivary glands of the left buccal mucosa with a rapid onset of multiple local and distant metastases, especially in the lung. A lung primary was unlikely as the tumour was characterized by positivity for cytokeratin 20 and negativity for the thyroid transcription factor-1 protein (TTF-1) in immunohistochemistry. CONCLUSION: A rare case of an adenocarcinoma (NOS) of the minor salivary glands with a rapid development and an unfavourable clinical course is reported. It shows that additional immunohistochemical analysis can decisively contribute to determine the site of the primary tumour in cases with unknown primary.
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spelling pubmed-25153012008-08-13 The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case Ettl, Tobias Kleinheinz, Johannes Mehrotra, Ravi Schwarz, Stephan Reichert, Torsten Eugen Driemel, Oliver Head Face Med Case Report BACKGROUND: With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly. CASE PRESENTATION: This paper describes a fast growing adenocarcinoma (NOS), originating from the minor salivary glands of the left buccal mucosa with a rapid onset of multiple local and distant metastases, especially in the lung. A lung primary was unlikely as the tumour was characterized by positivity for cytokeratin 20 and negativity for the thyroid transcription factor-1 protein (TTF-1) in immunohistochemistry. CONCLUSION: A rare case of an adenocarcinoma (NOS) of the minor salivary glands with a rapid development and an unfavourable clinical course is reported. It shows that additional immunohistochemical analysis can decisively contribute to determine the site of the primary tumour in cases with unknown primary. BioMed Central 2008-07-30 /pmc/articles/PMC2515301/ /pubmed/18667060 http://dx.doi.org/10.1186/1746-160X-4-16 Text en Copyright © 2008 Ettl et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ettl, Tobias
Kleinheinz, Johannes
Mehrotra, Ravi
Schwarz, Stephan
Reichert, Torsten Eugen
Driemel, Oliver
The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title_full The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title_fullStr The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title_full_unstemmed The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title_short The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
title_sort buccal minor salivary glands as starting point for a metastasizing adenocarcinoma – report of a case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515301/
https://www.ncbi.nlm.nih.gov/pubmed/18667060
http://dx.doi.org/10.1186/1746-160X-4-16
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