New steroidal aromatase inhibitors: Suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death

BACKGROUND: Aromatase, the cytochrome P-450 enzyme (CYP19) responsible for estrogen biosynthesis, is an important target for the treatment of estrogen-dependent breast cancer. In fact, the use of synthetic aromatase inhibitors (AI), which induce suppression of estrogen synthesis, has shown to be an...

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Detalles Bibliográficos
Autores principales: Cepa, Margarida, Correia-da-Silva, Georgina, da Silva, Elisiário J Tavares, Roleira, Fernanda MF, Borges, Margarida, Teixeira, Natércia A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515307/
https://www.ncbi.nlm.nih.gov/pubmed/18652661
http://dx.doi.org/10.1186/1471-2121-9-41

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