HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

To facilitate viral infection and spread, HIV-1 Nef disrupts the surface expression of the viral receptor (CD4) and molecules capable of presenting HIV antigens to the immune system (MHC-I). To accomplish this, Nef binds to the cytoplasmic tails of both molecules and then, by mechanisms that are not...

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Detalles Bibliográficos
Autores principales: Schaefer, Malinda R., Wonderlich, Elizabeth R., Roeth, Jeremiah F., Leonard, Jolie A., Collins, Kathleen L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515349/
https://www.ncbi.nlm.nih.gov/pubmed/18725938
http://dx.doi.org/10.1371/journal.ppat.1000131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515349/
https://www.ncbi.nlm.nih.gov/pubmed/18725938
http://dx.doi.org/10.1371/journal.ppat.1000131

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