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The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration
OBJECTIVE: An ulcer categorized as Fontaine’s stage IV represents a chronic wound, risk factor of arteriosclerosis, and co-morbidities which disturb wound healing. Our objective was to analyze wound healing and to assess potential factors affecting the healing process. METHODS: 199 patients were inc...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515428/ https://www.ncbi.nlm.nih.gov/pubmed/18827918 |
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author | Tautenhahn, Joerg Lobmann, Ralf Koenig, Brigitte Halloul, Zuhir Lippert, Hans Buerger, Thomas |
author_facet | Tautenhahn, Joerg Lobmann, Ralf Koenig, Brigitte Halloul, Zuhir Lippert, Hans Buerger, Thomas |
author_sort | Tautenhahn, Joerg |
collection | PubMed |
description | OBJECTIVE: An ulcer categorized as Fontaine’s stage IV represents a chronic wound, risk factor of arteriosclerosis, and co-morbidities which disturb wound healing. Our objective was to analyze wound healing and to assess potential factors affecting the healing process. METHODS: 199 patients were included in this 5-year study. The significance levels were determined by chi-squared and log-rank tests. The calculation of patency rate followed the Kaplan-Meier method. RESULTS: Mean age and co-morbidities did not differ from those in current epidemiological studies. Of the patients with ulcer latency of more than 13 weeks (up to one year), 40% required vascular surgery. Vascular surgery was not possible for 53 patients and they were treated conservatively. The amputation rate in the conservatively treated group was 37%, whereas in the revascularizated group it was only 16%. Ulcers in patients with revascularization healed in 92% of cases after 24 weeks. In contrast, we found a healing rate of only 40% in the conservatively treated group (p < 0.001). Revascularization appeared more often in diabetic patients (n = 110; p < 0.01) and the wound size and number of infections were elevated (p = 0.03). Among those treated conservatively, wound healing was decelerated (p = 0.01/0.02; χ(2) test). CONCLUSIONS: The success of revascularization, presence of diabetes mellitus, and wound treatment proved to be prognostic factors for wound healing in arterial ulcers. |
format | Text |
id | pubmed-2515428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25154282008-10-01 The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration Tautenhahn, Joerg Lobmann, Ralf Koenig, Brigitte Halloul, Zuhir Lippert, Hans Buerger, Thomas Vasc Health Risk Manag Original Research OBJECTIVE: An ulcer categorized as Fontaine’s stage IV represents a chronic wound, risk factor of arteriosclerosis, and co-morbidities which disturb wound healing. Our objective was to analyze wound healing and to assess potential factors affecting the healing process. METHODS: 199 patients were included in this 5-year study. The significance levels were determined by chi-squared and log-rank tests. The calculation of patency rate followed the Kaplan-Meier method. RESULTS: Mean age and co-morbidities did not differ from those in current epidemiological studies. Of the patients with ulcer latency of more than 13 weeks (up to one year), 40% required vascular surgery. Vascular surgery was not possible for 53 patients and they were treated conservatively. The amputation rate in the conservatively treated group was 37%, whereas in the revascularizated group it was only 16%. Ulcers in patients with revascularization healed in 92% of cases after 24 weeks. In contrast, we found a healing rate of only 40% in the conservatively treated group (p < 0.001). Revascularization appeared more often in diabetic patients (n = 110; p < 0.01) and the wound size and number of infections were elevated (p = 0.03). Among those treated conservatively, wound healing was decelerated (p = 0.01/0.02; χ(2) test). CONCLUSIONS: The success of revascularization, presence of diabetes mellitus, and wound treatment proved to be prognostic factors for wound healing in arterial ulcers. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2515428/ /pubmed/18827918 Text en © 2008 Tautenhahn et al, publisher and licensee Dove Medical Press Ltd. |
spellingShingle | Original Research Tautenhahn, Joerg Lobmann, Ralf Koenig, Brigitte Halloul, Zuhir Lippert, Hans Buerger, Thomas The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title | The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title_full | The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title_fullStr | The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title_full_unstemmed | The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title_short | The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
title_sort | influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515428/ https://www.ncbi.nlm.nih.gov/pubmed/18827918 |
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