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GABA(A) Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

Advanced age and mutations in the genes encoding amyloid precursor protein (APP) and presenilin (PS1) are two serious risk factors for Alzheimer's disease (AD). Finding common pathogenic changes originating from these risks may lead to a new therapeutic strategy. We observed a decline in memory...

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Detalles Bibliográficos
Autores principales:	Yoshiike, Yuji, Kimura, Tetsuya, Yamashita, Shunji, Furudate, Hiroyuki, Mizoroki, Tatsuya, Murayama, Miyuki, Takashima, Akihiko
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515633/ https://www.ncbi.nlm.nih.gov/pubmed/18716656 http://dx.doi.org/10.1371/journal.pone.0003029

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