Cargando…

First true initial ictal SPECT in partial epilepsy verified by electroencephalography

Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion...

Descripción completa

Detalles Bibliográficos
Autores principales: Pastor, Jesús, Domínguez-Gadea, Luis, Sola, Rafael G, Hernando, Virgilio, Meilán, María Luisa, Dios, Eva De, Martínez-Chacón, José Luis, Martínez, Marcos
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515897/
https://www.ncbi.nlm.nih.gov/pubmed/18728803
_version_ 1782158450144313344
author Pastor, Jesús
Domínguez-Gadea, Luis
Sola, Rafael G
Hernando, Virgilio
Meilán, María Luisa
Dios, Eva De
Martínez-Chacón, José Luis
Martínez, Marcos
author_facet Pastor, Jesús
Domínguez-Gadea, Luis
Sola, Rafael G
Hernando, Virgilio
Meilán, María Luisa
Dios, Eva De
Martínez-Chacón, José Luis
Martínez, Marcos
author_sort Pastor, Jesús
collection PubMed
description Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion observed is produced by diffusion of ictal activity. Here we describe a patient studied with v-EEG and foramen ovale electrodes that suffered a seizure after intravenous infusion of etomidate. The sequence of etomidate administration, followed by radiotracer and seizure was good enough for us to suspect that a true initial ictal SPECT was observed. We have implemented a kinetic model with four compartments, previously described (Andersen 1989), in order to estimate the fraction of hydrophilic radiotracer in the brain during the pre-ictal and ictal periods. This model has shown that the fraction of hydrophilic radiotracer during the seizure into the brain would be between 18.9% and 42.3% of total infused. We show the first true initial ictal SPECT demonstrated by bioelectrical recordings of the brain activity, obtained by a correct succession of events and compatible with theoretical data obtained from the kinetic model.
format Text
id pubmed-2515897
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-25158972008-08-26 First true initial ictal SPECT in partial epilepsy verified by electroencephalography Pastor, Jesús Domínguez-Gadea, Luis Sola, Rafael G Hernando, Virgilio Meilán, María Luisa Dios, Eva De Martínez-Chacón, José Luis Martínez, Marcos Neuropsychiatr Dis Treat Case Report Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion observed is produced by diffusion of ictal activity. Here we describe a patient studied with v-EEG and foramen ovale electrodes that suffered a seizure after intravenous infusion of etomidate. The sequence of etomidate administration, followed by radiotracer and seizure was good enough for us to suspect that a true initial ictal SPECT was observed. We have implemented a kinetic model with four compartments, previously described (Andersen 1989), in order to estimate the fraction of hydrophilic radiotracer in the brain during the pre-ictal and ictal periods. This model has shown that the fraction of hydrophilic radiotracer during the seizure into the brain would be between 18.9% and 42.3% of total infused. We show the first true initial ictal SPECT demonstrated by bioelectrical recordings of the brain activity, obtained by a correct succession of events and compatible with theoretical data obtained from the kinetic model. Dove Medical Press 2008-02 2008-02 /pmc/articles/PMC2515897/ /pubmed/18728803 Text en © 2006 Pastor et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Case Report
Pastor, Jesús
Domínguez-Gadea, Luis
Sola, Rafael G
Hernando, Virgilio
Meilán, María Luisa
Dios, Eva De
Martínez-Chacón, José Luis
Martínez, Marcos
First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_full First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_fullStr First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_full_unstemmed First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_short First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_sort first true initial ictal spect in partial epilepsy verified by electroencephalography
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515897/
https://www.ncbi.nlm.nih.gov/pubmed/18728803
work_keys_str_mv AT pastorjesus firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT dominguezgadealuis firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT solarafaelg firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT hernandovirgilio firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT meilanmarialuisa firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT diosevade firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT martinezchaconjoseluis firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography
AT martinezmarcos firsttrueinitialictalspectinpartialepilepsyverifiedbyelectroencephalography