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Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes
Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated iron. The only way to treat transfusion-induced iron overload is iron chelating therapy. However, most patients...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516546/ https://www.ncbi.nlm.nih.gov/pubmed/18581199 http://dx.doi.org/10.1007/s12185-008-0119-y |
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author | Suzuki, Takahiro Tomonaga, Masao Miyazaki, Yasushi Nakao, Shinji Ohyashiki, Kazuma Matsumura, Itaru Kohgo, Yutaka Niitsu, Yoshiro Kojima, Seiji Ozawa, Keiya |
author_facet | Suzuki, Takahiro Tomonaga, Masao Miyazaki, Yasushi Nakao, Shinji Ohyashiki, Kazuma Matsumura, Itaru Kohgo, Yutaka Niitsu, Yoshiro Kojima, Seiji Ozawa, Keiya |
author_sort | Suzuki, Takahiro |
collection | PubMed |
description | Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated iron. The only way to treat transfusion-induced iron overload is iron chelating therapy. However, most patients have not been treated effectively because daily/continuous administration of deferoxamine is difficult for outpatients. Recently, a novel oral iron chelator, deferasirox, has been developed, and introduction of the drug may help many patients benefit from iron chelation therapy. In this review, we will discuss the current status of iron overload in transfusion-dependent patients, and the development of Japanese guidelines for the treatment of iron overload in Japan, which were established by the National Research Group on Idiopathic Bone Marrow Failure Syndromes in Japan. |
format | Text |
id | pubmed-2516546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-25165462008-08-15 Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes Suzuki, Takahiro Tomonaga, Masao Miyazaki, Yasushi Nakao, Shinji Ohyashiki, Kazuma Matsumura, Itaru Kohgo, Yutaka Niitsu, Yoshiro Kojima, Seiji Ozawa, Keiya Int J Hematol Progress in Hematology Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated iron. The only way to treat transfusion-induced iron overload is iron chelating therapy. However, most patients have not been treated effectively because daily/continuous administration of deferoxamine is difficult for outpatients. Recently, a novel oral iron chelator, deferasirox, has been developed, and introduction of the drug may help many patients benefit from iron chelation therapy. In this review, we will discuss the current status of iron overload in transfusion-dependent patients, and the development of Japanese guidelines for the treatment of iron overload in Japan, which were established by the National Research Group on Idiopathic Bone Marrow Failure Syndromes in Japan. Springer Japan 2008-06-27 2008 /pmc/articles/PMC2516546/ /pubmed/18581199 http://dx.doi.org/10.1007/s12185-008-0119-y Text en © The Japanese Society of Hematology 2008 |
spellingShingle | Progress in Hematology Suzuki, Takahiro Tomonaga, Masao Miyazaki, Yasushi Nakao, Shinji Ohyashiki, Kazuma Matsumura, Itaru Kohgo, Yutaka Niitsu, Yoshiro Kojima, Seiji Ozawa, Keiya Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title | Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title_full | Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title_fullStr | Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title_full_unstemmed | Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title_short | Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
title_sort | japanese epidemiological survey with consensus statement on japanese guidelines for treatment of iron overload in bone marrow failure syndromes |
topic | Progress in Hematology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516546/ https://www.ncbi.nlm.nih.gov/pubmed/18581199 http://dx.doi.org/10.1007/s12185-008-0119-y |
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