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Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia

Mutations affecting NPM1 (nucleophosmin) are the most common genetic lesions found in acute myeloid leukemia (AML). NPM1 is one of the most abundant proteins found in the nucleolus and has links to the MDM2/p53 tumor suppressor pathway. A distinctive feature of NPM1 mutants in AML is their aberrant...

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Detalles Bibliográficos
Autores principales:	Grummitt, Charles G., Townsley, Fiona M., Johnson, Christopher M., Warren, Alan J., Bycroft, Mark
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516977/ https://www.ncbi.nlm.nih.gov/pubmed/18511415 http://dx.doi.org/10.1074/jbc.M801706200

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