Targeting focal adhesions:Helicobacter pylori-host communication in cell migration

Highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. The human pathogen Helicobacter pylori (H. pylori) directly targets integrins with drastic consequences on the epithelial cell mo...

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Detalles Bibliográficos
Autores principales: Schneider, Sabine, Weydig, Christiane, Wessler, Silja
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517590/
https://www.ncbi.nlm.nih.gov/pubmed/18684322
http://dx.doi.org/10.1186/1478-811X-6-2
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author Schneider, Sabine
Weydig, Christiane
Wessler, Silja
author_facet Schneider, Sabine
Weydig, Christiane
Wessler, Silja
author_sort Schneider, Sabine
collection PubMed
description Highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. The human pathogen Helicobacter pylori (H. pylori) directly targets integrins with drastic consequences on the epithelial cell morphology and migration, which might contribute to the disruption of the gastric epithelium in vivo. In this review, we summarize the recent findings concerning the complex mechanism through which H. pylori interferes with host integrin signaling thereby deregulating focal adhesions and the actin cytoskeleton of motile epithelial cells.
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spelling pubmed-25175902008-08-19 Targeting focal adhesions:Helicobacter pylori-host communication in cell migration Schneider, Sabine Weydig, Christiane Wessler, Silja Cell Commun Signal Review Highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. The human pathogen Helicobacter pylori (H. pylori) directly targets integrins with drastic consequences on the epithelial cell morphology and migration, which might contribute to the disruption of the gastric epithelium in vivo. In this review, we summarize the recent findings concerning the complex mechanism through which H. pylori interferes with host integrin signaling thereby deregulating focal adhesions and the actin cytoskeleton of motile epithelial cells. BioMed Central 2008-08-06 /pmc/articles/PMC2517590/ /pubmed/18684322 http://dx.doi.org/10.1186/1478-811X-6-2 Text en Copyright © 2008 Schneider et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Schneider, Sabine
Weydig, Christiane
Wessler, Silja
Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title_full Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title_fullStr Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title_full_unstemmed Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title_short Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
title_sort targeting focal adhesions:helicobacter pylori-host communication in cell migration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517590/
https://www.ncbi.nlm.nih.gov/pubmed/18684322
http://dx.doi.org/10.1186/1478-811X-6-2
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