Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

BACKGROUND: Molecular characterisation of normal karyotype acute myeloid leukemia (NK-AML) allows prognostic stratification and potentially can alter treatment choices and pathways. Approximately 45–60% of patients with NK-AML carry NPM1 gene mutations and are associated with a favourable clinical o...

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Detalles Bibliográficos
Autores principales: Tan, Angela YC, Westerman, David A, Carney, Dennis A, Seymour, John F, Juneja, Surender, Dobrovic, Alexander
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517593/
https://www.ncbi.nlm.nih.gov/pubmed/18664261
http://dx.doi.org/10.1186/1756-8722-1-10

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