Arf family GTP loading is activated by, and generates, positive membrane curvature

Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curva...

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Autores principales: Lundmark, Richard, Doherty, Gary J., Vallis, Yvonne, Peter, Brian J., McMahon, Harvey T.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2008
Materias:
Accelerated Publication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518064/
https://www.ncbi.nlm.nih.gov/pubmed/18597672
http://dx.doi.org/10.1042/BJ20081237
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author Lundmark, Richard
Doherty, Gary J.
Vallis, Yvonne
Peter, Brian J.
McMahon, Harvey T.
author_facet Lundmark, Richard
Doherty, Gary J.
Vallis, Yvonne
Peter, Brian J.
McMahon, Harvey T.
author_sort Lundmark, Richard
collection PubMed
description Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.
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spelling pubmed-25180642008-10-07 Arf family GTP loading is activated by, and generates, positive membrane curvature Lundmark, Richard Doherty, Gary J. Vallis, Yvonne Peter, Brian J. McMahon, Harvey T. Biochem J Accelerated Publication Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix. Portland Press Ltd. 2008-08-12 2008-09-01 /pmc/articles/PMC2518064/ /pubmed/18597672 http://dx.doi.org/10.1042/BJ20081237 Text en © 2008 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Accelerated Publication
Lundmark, Richard
Doherty, Gary J.
Vallis, Yvonne
Peter, Brian J.
McMahon, Harvey T.
Arf family GTP loading is activated by, and generates, positive membrane curvature
title Arf family GTP loading is activated by, and generates, positive membrane curvature
title_full Arf family GTP loading is activated by, and generates, positive membrane curvature
title_fullStr Arf family GTP loading is activated by, and generates, positive membrane curvature
title_full_unstemmed Arf family GTP loading is activated by, and generates, positive membrane curvature
title_short Arf family GTP loading is activated by, and generates, positive membrane curvature
title_sort arf family gtp loading is activated by, and generates, positive membrane curvature
topic Accelerated Publication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518064/
https://www.ncbi.nlm.nih.gov/pubmed/18597672
http://dx.doi.org/10.1042/BJ20081237
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