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Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal prin...

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Detalles Bibliográficos
Autores principales: Boone, Michelle, Deen, Peter M. T.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518081/
https://www.ncbi.nlm.nih.gov/pubmed/18431594
http://dx.doi.org/10.1007/s00424-008-0498-1
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author Boone, Michelle
Deen, Peter M. T.
author_facet Boone, Michelle
Deen, Peter M. T.
author_sort Boone, Michelle
collection PubMed
description To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease.
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spelling pubmed-25180812008-08-20 Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption Boone, Michelle Deen, Peter M. T. Pflugers Arch Invited Review To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease. Springer-Verlag 2008-04-23 2008 /pmc/articles/PMC2518081/ /pubmed/18431594 http://dx.doi.org/10.1007/s00424-008-0498-1 Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Invited Review
Boone, Michelle
Deen, Peter M. T.
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title_full Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title_fullStr Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title_full_unstemmed Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title_short Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
title_sort physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518081/
https://www.ncbi.nlm.nih.gov/pubmed/18431594
http://dx.doi.org/10.1007/s00424-008-0498-1
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