CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer

BACKGROUND: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing...

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Detalles Bibliográficos
Autores principales: Chrisanthar, Ranjan, Knappskog, Stian, Løkkevik, Erik, Anker, Gun, Østenstad, Bjørn, Lundgren, Steinar, Berge, Elisabet O., Risberg, Terje, Mjaaland, Ingvil, Mæhle, Lovise, Engebretsen, Lars Fredrik, Lillehaug, Johan Richard, Lønning, Per Eystein
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518116/
https://www.ncbi.nlm.nih.gov/pubmed/18725978
http://dx.doi.org/10.1371/journal.pone.0003062

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