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Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time

OBJECTIVE—Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13–35 years) have lower BMD than community age-matched nondiabetic control subjects...

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Autores principales: Mastrandrea, Lucy D., Wactawski-Wende, Jean, Donahue, Richard P., Hovey, Kathleen M., Clark, Angela, Quattrin, Teresa
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518333/
https://www.ncbi.nlm.nih.gov/pubmed/18591404
http://dx.doi.org/10.2337/dc07-2426
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author Mastrandrea, Lucy D.
Wactawski-Wende, Jean
Donahue, Richard P.
Hovey, Kathleen M.
Clark, Angela
Quattrin, Teresa
author_facet Mastrandrea, Lucy D.
Wactawski-Wende, Jean
Donahue, Richard P.
Hovey, Kathleen M.
Clark, Angela
Quattrin, Teresa
author_sort Mastrandrea, Lucy D.
collection PubMed
description OBJECTIVE—Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13–35 years) have lower BMD than community age-matched nondiabetic control subjects. We here report 2-year follow-up BMD data in this cohort to determine the natural history of BMD in young women with and without diabetes. RESEARCH DESIGN AND METHODS—BMD was measured by dual-energy X-ray absorptiometry at baseline and 2 years later in 63 women with type 1 diabetes and in 85 age-matched community control subjects. A1C, IGF-1, IGF binding protein-3, serum osteocalcin, and urine N-teleopeptide were measured at follow-up. RESULTS—After adjusting for age, BMI, and oral contraceptive use, BMD at year 2 continued to be lower in women ≥20 years of age with type 1 diabetes compared with control subjects at the total hip, femoral neck, and whole body. Lower BMD values were observed in cases <20 years of age compared with control subjects; however, the differences were not statistically significant. Lower BMD did not correlate with diabetes control, growth factors, or metabolic bone markers. CONCLUSIONS—This study confirms our previous findings that young women with type 1 diabetes have lower BMD than control subjects and that these differences persist over time, particularly in women ≥20 years of age. Persistence of low BMD as well as failure to accrue bone density after age 20 years may contribute to the increased incidence of osteoporotic hip fractures seen in postmenopausal women with type 1 diabetes.
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spelling pubmed-25183332009-09-01 Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time Mastrandrea, Lucy D. Wactawski-Wende, Jean Donahue, Richard P. Hovey, Kathleen M. Clark, Angela Quattrin, Teresa Diabetes Care Clinical Care/Education/Nutrition/Psychosocial Research OBJECTIVE—Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13–35 years) have lower BMD than community age-matched nondiabetic control subjects. We here report 2-year follow-up BMD data in this cohort to determine the natural history of BMD in young women with and without diabetes. RESEARCH DESIGN AND METHODS—BMD was measured by dual-energy X-ray absorptiometry at baseline and 2 years later in 63 women with type 1 diabetes and in 85 age-matched community control subjects. A1C, IGF-1, IGF binding protein-3, serum osteocalcin, and urine N-teleopeptide were measured at follow-up. RESULTS—After adjusting for age, BMI, and oral contraceptive use, BMD at year 2 continued to be lower in women ≥20 years of age with type 1 diabetes compared with control subjects at the total hip, femoral neck, and whole body. Lower BMD values were observed in cases <20 years of age compared with control subjects; however, the differences were not statistically significant. Lower BMD did not correlate with diabetes control, growth factors, or metabolic bone markers. CONCLUSIONS—This study confirms our previous findings that young women with type 1 diabetes have lower BMD than control subjects and that these differences persist over time, particularly in women ≥20 years of age. Persistence of low BMD as well as failure to accrue bone density after age 20 years may contribute to the increased incidence of osteoporotic hip fractures seen in postmenopausal women with type 1 diabetes. American Diabetes Association 2008-09 /pmc/articles/PMC2518333/ /pubmed/18591404 http://dx.doi.org/10.2337/dc07-2426 Text en Copyright © 2008, DIABETES CARE Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Clinical Care/Education/Nutrition/Psychosocial Research
Mastrandrea, Lucy D.
Wactawski-Wende, Jean
Donahue, Richard P.
Hovey, Kathleen M.
Clark, Angela
Quattrin, Teresa
Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title_full Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title_fullStr Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title_full_unstemmed Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title_short Young Women With Type 1 Diabetes Have Lower Bone Mineral Density That Persists Over Time
title_sort young women with type 1 diabetes have lower bone mineral density that persists over time
topic Clinical Care/Education/Nutrition/Psychosocial Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518333/
https://www.ncbi.nlm.nih.gov/pubmed/18591404
http://dx.doi.org/10.2337/dc07-2426
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