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Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors

OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND ME...

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Autores principales: Diamantopoulos, Stavros, Allende, Gloria, Ferreira, Joseph M., Ciancio, Gaetano, Burke, George W., Pugliese, Alberto
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518336/
https://www.ncbi.nlm.nih.gov/pubmed/18556338
http://dx.doi.org/10.2337/dc08-0652
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author Diamantopoulos, Stavros
Allende, Gloria
Ferreira, Joseph M.
Ciancio, Gaetano
Burke, George W.
Pugliese, Alberto
author_facet Diamantopoulos, Stavros
Allende, Gloria
Ferreira, Joseph M.
Ciancio, Gaetano
Burke, George W.
Pugliese, Alberto
author_sort Diamantopoulos, Stavros
collection PubMed
description OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS—We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2-AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years after transplant. The recipient of the insulin-AAb–positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS—Single AAb positivity did not affect the outcome of pancreas transplantation in our study.
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spelling pubmed-25183362009-09-01 Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors Diamantopoulos, Stavros Allende, Gloria Ferreira, Joseph M. Ciancio, Gaetano Burke, George W. Pugliese, Alberto Diabetes Care Clinical Care/Education/Nutrition/Psychosocial Research OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS—We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2-AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years after transplant. The recipient of the insulin-AAb–positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS—Single AAb positivity did not affect the outcome of pancreas transplantation in our study. American Diabetes Association 2008-09 /pmc/articles/PMC2518336/ /pubmed/18556338 http://dx.doi.org/10.2337/dc08-0652 Text en Copyright © 2008, DIABETES CARE Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Clinical Care/Education/Nutrition/Psychosocial Research
Diamantopoulos, Stavros
Allende, Gloria
Ferreira, Joseph M.
Ciancio, Gaetano
Burke, George W.
Pugliese, Alberto
Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title_full Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title_fullStr Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title_full_unstemmed Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title_short Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
title_sort retrospective assessment of islet cell autoantibodies in pancreas organ donors
topic Clinical Care/Education/Nutrition/Psychosocial Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518336/
https://www.ncbi.nlm.nih.gov/pubmed/18556338
http://dx.doi.org/10.2337/dc08-0652
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