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Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND ME...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518336/ https://www.ncbi.nlm.nih.gov/pubmed/18556338 http://dx.doi.org/10.2337/dc08-0652 |
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author | Diamantopoulos, Stavros Allende, Gloria Ferreira, Joseph M. Ciancio, Gaetano Burke, George W. Pugliese, Alberto |
author_facet | Diamantopoulos, Stavros Allende, Gloria Ferreira, Joseph M. Ciancio, Gaetano Burke, George W. Pugliese, Alberto |
author_sort | Diamantopoulos, Stavros |
collection | PubMed |
description | OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS—We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2-AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years after transplant. The recipient of the insulin-AAb–positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS—Single AAb positivity did not affect the outcome of pancreas transplantation in our study. |
format | Text |
id | pubmed-2518336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-25183362009-09-01 Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors Diamantopoulos, Stavros Allende, Gloria Ferreira, Joseph M. Ciancio, Gaetano Burke, George W. Pugliese, Alberto Diabetes Care Clinical Care/Education/Nutrition/Psychosocial Research OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation. RESEARCH DESIGN AND METHODS—We retrospectively tested AAb in 135 donors whose pancreata and kidneys were transplanted in type 1 diabetes patients. We measured AAb to glutamic acid decarboxylase (GAD-AAb), the tyrosine-phosphatase-like protein IA2 (IA2-AAb), and insulin (insulin-AAb). We then evaluated pancreas transplant outcome data. RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and one donor had insulin-AAb. Their respective recipients became insulin independent on follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years after transplant. The recipient of the insulin-AAb–positive donor pancreas developed chronic rejection following discontinuation of immunosuppression 3.3 years after transplant. CONCLUSIONS—Single AAb positivity did not affect the outcome of pancreas transplantation in our study. American Diabetes Association 2008-09 /pmc/articles/PMC2518336/ /pubmed/18556338 http://dx.doi.org/10.2337/dc08-0652 Text en Copyright © 2008, DIABETES CARE Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Clinical Care/Education/Nutrition/Psychosocial Research Diamantopoulos, Stavros Allende, Gloria Ferreira, Joseph M. Ciancio, Gaetano Burke, George W. Pugliese, Alberto Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title | Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title_full | Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title_fullStr | Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title_full_unstemmed | Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title_short | Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors |
title_sort | retrospective assessment of islet cell autoantibodies in pancreas organ donors |
topic | Clinical Care/Education/Nutrition/Psychosocial Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518336/ https://www.ncbi.nlm.nih.gov/pubmed/18556338 http://dx.doi.org/10.2337/dc08-0652 |
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