Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

The present study evaluated 17β-estradiol (17βE(2)) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-...

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Autores principales: Tasset, Inmaculada, Peña, José, Jimena, Ignacio, Feijóo, Montserrat, del Carmen Muñoz, María, Montilla, Pedro, Túnez, Isaac
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518376/
https://www.ncbi.nlm.nih.gov/pubmed/18728794
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author Tasset, Inmaculada
Peña, José
Jimena, Ignacio
Feijóo, Montserrat
del Carmen Muñoz, María
Montilla, Pedro
Túnez, Isaac
author_facet Tasset, Inmaculada
Peña, José
Jimena, Ignacio
Feijóo, Montserrat
del Carmen Muñoz, María
Montilla, Pedro
Túnez, Isaac
author_sort Tasset, Inmaculada
collection PubMed
description The present study evaluated 17β-estradiol (17βE(2)) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE(2) (14 days). Our results reveled that 17βE(2) has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.
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spelling pubmed-25183762008-08-26 Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats Tasset, Inmaculada Peña, José Jimena, Ignacio Feijóo, Montserrat del Carmen Muñoz, María Montilla, Pedro Túnez, Isaac Neuropsychiatr Dis Treat Original Research The present study evaluated 17β-estradiol (17βE(2)) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE(2) (14 days). Our results reveled that 17βE(2) has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties. Dove Medical Press 2008-04 2008-04 /pmc/articles/PMC2518376/ /pubmed/18728794 Text en © 2008 Tasset et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Original Research
Tasset, Inmaculada
Peña, José
Jimena, Ignacio
Feijóo, Montserrat
del Carmen Muñoz, María
Montilla, Pedro
Túnez, Isaac
Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_full Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_fullStr Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_full_unstemmed Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_short Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_sort effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518376/
https://www.ncbi.nlm.nih.gov/pubmed/18728794
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