Cargando…

Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation

OBJECTIVE—β-Cell proliferation is an important mechanism underlying β-cell mass adaptation to metabolic demands. We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in β-cells. RESEARCH DESIGN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Woo-Jin, Schreiber, Weston E., Zhong, Enhong, Liu, Fei-Fei, Kornfeld, Benjamin D., Wondisford, Fredric E., Hussain, Mehboob A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518488/ https://www.ncbi.nlm.nih.gov/pubmed/18544709 http://dx.doi.org/10.2337/db07-1541

Ejemplares similares

(111)In-exendin Uptake in the Pancreas Correlates With the β-Cell Mass and Not With the α-Cell Mass
por: Brom, Maarten, et al.
Publicado: (2015)

Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression
por: Guthalu Kondegowda, Nagesha, et al.
Publicado: (2010)

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2016)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
por: Kumar, Anil, et al.
Publicado: (2018)

Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
por: Mukai, Eri, et al.
Publicado: (2011)

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2
por: Lakshmipathi, Jayalakshmi, et al.
Publicado: (2016)

Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways
por: Daval, Marie, et al.
Publicado: (2011)

Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish
por: Maddison, Lisette A., et al.
Publicado: (2012)

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2014)

Virgin β-Cells at the Neogenic Niche Proliferate Normally and Mature Slowly
por: Lee, Sharon, et al.
Publicado: (2021)

Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
por: Lam, Carol J., et al.
Publicado: (2019)

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice
por: Riley, Kimberly G., et al.
Publicado: (2015)

HES-1 Is Involved in Adaptation of Adult Human β-Cells to Proliferation In Vitro
por: Bar, Yael, et al.
Publicado: (2008)

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
por: Maachi, Hasna, et al.
Publicado: (2020)

Quantification of β-Cell Mass in Intramuscular Islet Grafts Using Radiolabeled Exendin-4
por: Espes, Daniel, et al.
Publicado: (2016)

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
por: Hinault, Charlotte, et al.
Publicado: (2011)

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells
por: Wang, You, et al.
Publicado: (2013)

Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
por: Wei, Jianwen, et al.
Publicado: (2014)

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
por: Kondo, Tatsuya, et al.
Publicado: (2012)

β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
por: Ackermann Misfeldt, Amanda, et al.
Publicado: (2008)

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
por: Chen, Hainan, et al.
Publicado: (2015)

Generation and Characterization of a Novel Mouse Model That Allows Spatiotemporal Quantification of Pancreatic β-Cell Proliferation
por: Tokumoto, Shinsuke, et al.
Publicado: (2020)

Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
por: Nguidjoe, Evrard, et al.
Publicado: (2011)

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
por: Gu, Yanyun, et al.
Publicado: (2011)

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
por: Spaeth, Jason M., et al.
Publicado: (2019)

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2010)

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
por: Spaeth, Jason M., et al.
Publicado: (2017)

Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1
por: Romer, Anthony I., et al.
Publicado: (2019)

Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
por: Bastien-Dionne, Pierre-Olivier, et al.
Publicado: (2011)

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells
por: Miyazaki, Satsuki, et al.
Publicado: (2010)

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
por: Georgiadou, Eleni, et al.
Publicado: (2022)

In Vitro Recovery of ATP-Sensitive Potassium Channels in β-Cells From Patients With Congenital Hyperinsulinism of Infancy
por: Powell, Philippa D., et al.
Publicado: (2011)

Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
por: Pascoe, Jordan, et al.
Publicado: (2012)

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
por: Zarrouki, Bader, et al.
Publicado: (2014)

Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells: Potential Involvement of the PLC-IP(3)–Dependent Pathway
por: Suzuki, Toshinobu, et al.
Publicado: (2011)

Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and K(ATP) Channel Inhibition
por: Düfer, Martina, et al.
Publicado: (2012)

Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice
por: Wei, Tianjiao, et al.
Publicado: (2023)

Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
por: Wang, Linyuan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_v4kp87drakaaprf34vimuvgfc7