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Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

OBJECTIVE—Chronic exposure to fatty acids causes β-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis. RESEARCH DESIGN AND METHODS—We studied in vitro and in vivo effects of saturated and p...

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Detalles Bibliográficos
Autores principales:	Kato, Toyonori, Shimano, Hitoshi, Yamamoto, Takashi, Ishikawa, Mayumi, Kumadaki, Shin, Matsuzaka, Takashi, Nakagawa, Yoshimi, Yahagi, Naoya, Nakakuki, Masanori, Hasty, Alyssa H., Takeuchi, Yoshinori, Kobayashi, Kazuto, Takahashi, Akimitsu, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Yamada, Nobuhiro
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518489/ https://www.ncbi.nlm.nih.gov/pubmed/18458149 http://dx.doi.org/10.2337/db06-1806

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