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Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

OBJECTIVE—Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed f...

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Detalles Bibliográficos
Autores principales:	Fukuda, Akihisa, Kawaguchi, Yoshiya, Furuyama, Kenichiro, Kodama, Sota, Horiguchi, Masashi, Kuhara, Takeshi, Kawaguchi, Michiya, Terao, Mami, Doi, Ryuichiro, Wright, Christopher V.E., Hoshino, Mikio, Chiba, Tsutomu, Uemoto, Shinji
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518493/ https://www.ncbi.nlm.nih.gov/pubmed/18591390 http://dx.doi.org/10.2337/db07-1558

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