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Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

OBJECTIVE— Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic cause of obesity. However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown. RESEA...

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Detalles Bibliográficos
Autores principales:	Stutzmann, Fanny, Tan, Karen, Vatin, Vincent, Dina, Christian, Jouret, Béatrice, Tichet, Jean, Balkau, Beverley, Potoczna, Natascha, Horber, Fritz, O'Rahilly, Stephen, Farooqi, I. Sadaf, Froguel, Philippe, Meyre, David
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518504/ https://www.ncbi.nlm.nih.gov/pubmed/18559663 http://dx.doi.org/10.2337/db08-0153

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