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N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease

BACKGROUND: Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended “synaptic” acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena. METHODOLOGY AND PRINCI...

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Detalles Bibliográficos
Autores principales:	Toiber, Debra, Berson, Amit, Greenberg, David, Melamed-Book, Naomi, Diamant, Sophia, Soreq, Hermona
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518620/ https://www.ncbi.nlm.nih.gov/pubmed/18769671 http://dx.doi.org/10.1371/journal.pone.0003108

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