Cargando…

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Signal transduction by transforming growth factor β (TGFβ) coordinates physiological responses in diverse cell types. TGFβ signals via type I and type II receptor serine/threonine kinases and intracellular Smad proteins that regulate transcription. Strength and duration of TGFβ signaling is largely...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kowanetz, Marcin, Lönn, Peter, Vanlandewijck, Michael, Kowanetz, Katarzyna, Heldin, Carl-Henrik, Moustakas, Aristidis
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518705/ https://www.ncbi.nlm.nih.gov/pubmed/18725536 http://dx.doi.org/10.1083/jcb.200804107

Ejemplares similares

The protein kinase SIK downregulates the polarity protein Par3
por: Vanlandewijck, Michael, et al.
Publicado: (2017)

Notch signaling is necessary for epithelial growth arrest by TGF-β
por: Niimi, Hideki, et al.
Publicado: (2007)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
por: Moustakas, Aristidis, et al.
Publicado: (2016)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom
por: Huminiecki, Lukasz, et al.
Publicado: (2009)

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
por: Bellomo, Claudia, et al.
Publicado: (2017)

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation
por: Morén, Anita, et al.
Publicado: (2019)

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2019)

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
por: Dahl, Markus, et al.
Publicado: (2014)

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
por: Gélabert, Caroline, et al.
Publicado: (2023)

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses
por: Hutchinson, Luke D., et al.
Publicado: (2020)

Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
por: Maturi, Varun, et al.
Publicado: (2018)

Nucleosome regulatory dynamics in response to TGFβ
por: Enroth, Stefan, et al.
Publicado: (2014)

TGF-β Signaling
por: Tzavlaki, Kalliopi, et al.
Publicado: (2020)

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
por: Song, Jie, et al.
Publicado: (2015)

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
por: Tsirigoti, Chrysoula, et al.
Publicado: (2022)

TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor
por: Sundar, Reshma, et al.
Publicado: (2015)

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness
por: Sundqvist, Anders, et al.
Publicado: (2020)

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
por: Carthy, Jon M., et al.
Publicado: (2016)

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition
por: Thuault, Sylvie, et al.
Publicado: (2006)

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
por: Raja, Erna, et al.
Publicado: (2015)

Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer
por: Rodrigues-Junior, Dorival Mendes, et al.
Publicado: (2022)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

Long non‐coding RNAs and TGF‐β signaling in cancer
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2020)

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
por: Song, Jie, et al.
Publicado: (2022)

Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on the H19 Imprinting Control Region Chromatin
por: Bergström, Rosita, et al.
Publicado: (2010)

Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells
por: Caja, Laia, et al.
Publicado: (2018)

TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition
por: Tsubakihara, Yutaro, et al.
Publicado: (2022)

SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway
por: Gao, Yuan, et al.
Publicado: (2023)

Nuts and bolts of the salt-inducible kinases (SIKs)
por: Darling, Nicola J., et al.
Publicado: (2021)

MAP kinase inhibitors stimulate T cell and anti-tumor activity in combination with blockade of the PD-L1/PD-1 interaction
por: Irving, Bryan A, et al.
Publicado: (2013)

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration
por: Ekman, Maria, et al.
Publicado: (2012)

The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition
por: Tan, E-Jean, et al.
Publicado: (2015)

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
por: Sundqvist, Anders, et al.
Publicado: (2019)

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2021)

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer
por: Mu, Yabing, et al.
Publicado: (2011)

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
por: Caja, Laia, et al.
Publicado: (2018)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e7idhhpodmm6vu79kumgf479f6