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Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins
Accumulation of misfolded oxidant-damaged proteins is characteristic of many diseases and aging. To understand how cells handle postsynthetically damaged proteins, we studied in Saccharomyces cerevisiae the effects on overall protein degradation of shifting from 30 to 38°C, exposure to reactive oxyg...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518706/ https://www.ncbi.nlm.nih.gov/pubmed/18725537 http://dx.doi.org/10.1083/jcb.200803022 |