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Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

Accumulation of misfolded oxidant-damaged proteins is characteristic of many diseases and aging. To understand how cells handle postsynthetically damaged proteins, we studied in Saccharomyces cerevisiae the effects on overall protein degradation of shifting from 30 to 38°C, exposure to reactive oxyg...

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Detalles Bibliográficos
Autores principales:	Medicherla, Balasubrahmanyam, Goldberg, Alfred L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518706/ https://www.ncbi.nlm.nih.gov/pubmed/18725537 http://dx.doi.org/10.1083/jcb.200803022

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