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Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α(IIb)β(3)
Hemostasis and thrombosis (blood clotting) involve fibrinogen binding to integrin α(IIb)β(3) on platelets, resulting in platelet aggregation. α(v)β(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen's α subunit. α(IIb)β(3) also binds to fibrinogen; however, it does so via an unstr...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518716/ https://www.ncbi.nlm.nih.gov/pubmed/18710925 http://dx.doi.org/10.1083/jcb.200801146 |