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Role of N-Terminal Amino Acids in the Potency of Anthrax Lethal Factor

Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the addition of two residues (His-Met) to the nat...

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Detalles Bibliográficos
Autores principales:	Gupta, Pradeep K., Moayeri, Mahtab, Crown, Devorah, Fattah, Rasem J., Leppla, Stephen H.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518864/ https://www.ncbi.nlm.nih.gov/pubmed/18769623 http://dx.doi.org/10.1371/journal.pone.0003130

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