Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development

BACKGROUND: R-Spondin1 (Rspo1) is a novel regulator of the Wnt/β-catenin signalling pathway. Loss-of-function mutations in human RSPO1 cause testicular differentiation in 46, XX females, pointing to a role in ovarian development. Here we report the cloning and comparative expression analysis of R-SP...

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Detalles Bibliográficos
Autores principales: Smith, Craig A, Shoemaker, Christina M, Roeszler, Kelly N, Queen, Joanna, Crews, David, Sinclair, Andrew H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519078/
https://www.ncbi.nlm.nih.gov/pubmed/18651984
http://dx.doi.org/10.1186/1471-213X-8-72

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