Cargando…

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), impairment of glial “Excitatory Amino Acid Transporters” (EAATs) together with an excess glutamate-release by invading immune cells causes excitotoxic damage of the central nervous system (CNS). In order...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melzer, Nico, Meuth, Sven G., Torres-Salazar, Delany, Bittner, Stefan, Zozulya, Alla L., Weidenfeller, Christian, Kotsiari, Alexandra, Stangel, Martin, Fahlke, Christoph, Wiendl, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522272/ https://www.ncbi.nlm.nih.gov/pubmed/18773080 http://dx.doi.org/10.1371/journal.pone.0003149

Ejemplares similares

Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis
por: Melzer, Nico, et al.
Publicado: (2008)

Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis
por: Melzer, Nico, et al.
Publicado: (2011)

Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8(+) T cell attack in the CNS gray matter
por: Melzer, Nico, et al.
Publicado: (2013)

Primary B Cell Lymphoma of the CNS Mimicking Anti-LGI1 Limbic Encephalitis
por: Thomas, Christian, et al.
Publicado: (2018)

Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond
por: Ruck, Tobias, et al.
Publicado: (2015)

Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system
por: Melzer, Nico, et al.
Publicado: (2012)

Pharmacological Approaches to Delaying Disability Progression in Patients with Multiple Sclerosis
por: Wiendl, Heinz, et al.
Publicado: (2015)

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation
por: Melzer, Nico, et al.
Publicado: (2012)

CD4(+ )CD25(+ )FoxP3(+ )regulatory T cells suppress cytotoxicity of CD8(+ )effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level
por: Göbel, Kerstin, et al.
Publicado: (2012)

Therapeutic Apheresis in Acute Relapsing Multiple Sclerosis: Current Evidence and Unmet Needs—A Systematic Review
por: Rolfes, Leoni, et al.
Publicado: (2019)

Cytotoxic CD8(+) T cells and CD138(+) plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies
por: Melzer, Nico, et al.
Publicado: (2012)

Myelin Oligodendrocyte Glycoprotein (MOG(35-55)) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
por: Bittner, Stefan, et al.
Publicado: (2014)

Comparing Plasma Exchange to Escalated Methyl Prednisolone in Refractory Multiple Sclerosis Relapses
por: Pfeuffer, Steffen, et al.
Publicado: (2019)

Long-term efficacy of alemtuzumab in polymyositis
por: Ruck, Tobias, et al.
Publicado: (2015)

Combined Neurofilament Light and Optical Coherence Tomography Better Predicts Multiple Sclerosis Disease Activity Than Either Measure Alone
por: Krämer, Julia, et al.
Publicado: (2021)

Gut–CNS-Axis as Possibility to Modulate Inflammatory Disease Activity—Implications for Multiple Sclerosis
por: Fleck, Ann-Katrin, et al.
Publicado: (2017)

Primary Angiitis of the CNS: A Systematic Review and Meta-analysis
por: Beuker, Carolin, et al.
Publicado: (2021)

Early and Degressive Putamen Atrophy in Multiple Sclerosis
por: Krämer, Julia, et al.
Publicado: (2015)

Trafficking of lymphocytes into the CNS
por: Schwab, Nicholas, et al.
Publicado: (2015)

ALAIN01—Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential
por: Ruck, Tobias, et al.
Publicado: (2016)

Generation of a Model to Predict Differentiation and Migration of Lymphocyte Subsets under Homeostatic and CNS Autoinflammatory Conditions
por: Gross, Catharina C., et al.
Publicado: (2020)

Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis
por: Keller, Christian W., et al.
Publicado: (2019)

DTI detects water diffusion abnormalities in the thalamus that correlate with an extremity pain episode in a patient with multiple sclerosis()
por: Deppe, Michael, et al.
Publicado: (2013)

Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis
por: Gross, Catharina C., et al.
Publicado: (2016)

Alemtuzumab Improves Cognitive Processing Speed in Active Multiple Sclerosis—A Longitudinal Observational Study
por: Riepl, Ester, et al.
Publicado: (2018)

Failed, Interrupted, or Inconclusive Trials on Immunomodulatory Treatment Strategies in Multiple Sclerosis: Update 2015–2020
por: Rolfes, Leoni, et al.
Publicado: (2020)

The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis
por: Masanneck, Lars, et al.
Publicado: (2020)

Failed, Interrupted, or Inconclusive Trials on Neuroprotective and Neuroregenerative Treatment Strategies in Multiple Sclerosis: Update 2015–2020
por: Huntemann, Niklas, et al.
Publicado: (2021)

Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses
por: Pfeuffer, Steffen, et al.
Publicado: (2022)

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis
por: Pfeuffer, Steffen, et al.
Publicado: (2021)

Alemtuzumab therapy changes immunoglobulin levels in peripheral blood and CSF
por: Möhn, Nora, et al.
Publicado: (2019)

Two pore domain potassium channels in cerebral ischemia: a focus on K(2P)9.1 (TASK3, KCNK9)
por: Ehling, Petra, et al.
Publicado: (2010)

Correction: Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
por: Ehling, Petra, et al.
Publicado: (2013)

Evans syndrome associated with sterile inflammation of the central nervous system: a case report
por: Simon, Ole Jan, et al.
Publicado: (2013)

The Agony of Choice? Preserved Affective Decision Making in Early Multiple Sclerosis
por: Landmeyer, Nils C., et al.
Publicado: (2020)

Evaluation of Age-Dependent Immune Signatures in Patients With Multiple Sclerosis
por: Eschborn, Melanie, et al.
Publicado: (2021)

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders
por: Brummer, Tobias, et al.
Publicado: (2021)

Onconeural antigen spreading in paraneoplastic neurological disease due to small cell lung cancer
por: Dik, Andre, et al.
Publicado: (2018)

Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis
por: Deppe, Michael, et al.
Publicado: (2014)

Skin Reactions in Patients With Multiple Sclerosis Receiving Cladribine Treatment
por: Rolfes, Leoni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i17ohq01b5mr7eaplnl8n7irre