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Cancer treatment: the combination of vaccination with other therapies

Harnessing of the immune system by the development of ‘therapeutic’ vaccines, for the battle against cancer has been the focus of tremendous research efforts over the past two decades. As an illustration of the impressive amounts of data gathered over the past years, numerous antigens expressed on t...

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Autores principales: Andersen, Mads Hald, Sørensen, Rikke Bæk, Schrama, David, Svane, Inge Marie, Becker, Jürgen C., thor Straten, Per
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522294/
https://www.ncbi.nlm.nih.gov/pubmed/18286284
http://dx.doi.org/10.1007/s00262-008-0480-y
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author Andersen, Mads Hald
Sørensen, Rikke Bæk
Schrama, David
Svane, Inge Marie
Becker, Jürgen C.
thor Straten, Per
author_facet Andersen, Mads Hald
Sørensen, Rikke Bæk
Schrama, David
Svane, Inge Marie
Becker, Jürgen C.
thor Straten, Per
author_sort Andersen, Mads Hald
collection PubMed
description Harnessing of the immune system by the development of ‘therapeutic’ vaccines, for the battle against cancer has been the focus of tremendous research efforts over the past two decades. As an illustration of the impressive amounts of data gathered over the past years, numerous antigens expressed on the surface of cancer cells, have been characterized. To this end, recent years research has focussed on characterization of antigens that play an important role for the growth and survival of cancer cells. Anti-apoptotic molecules like survivin that enhance the survival of cancer cells and facilitate their escape from cytotoxic therapies represent prime vaccination candidates. The characterization of a high number of tumor antigens allow the concurrent or serial immunological targeting of different proteins associated with such cancer traits. Moreover, while vaccination in itself is a promising new approach to fight cancer, the combination with additional therapy could create a number of synergistic effects. Herein we discuss the possibilities and prospects of vaccination when combined with other treatments. In this regard, cell death upon drug exposure may be immunogenic or non-immunogenic depending on the specific chemotherapeutics. Also, chemotherapy represents one of several options available for clearance of CD4(+) Foxp3(+) regulatory T cells. Moreover, therapies based on monoclonal antibodies may have synergistic potential in combination with vaccination, both when used for targeting of tumor cells and endothelial cells. The efficacy of therapeutic vaccination against cancer will over the next few years be studied in settings taking advantage of strategies in which vaccination is combined with other treatment modalities. These combinations should be based on current knowledge not only regarding the biology of the cancer cell per se, but also considering how treatment may influence the malignant cell population as well as the immune system.
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spelling pubmed-25222942008-08-27 Cancer treatment: the combination of vaccination with other therapies Andersen, Mads Hald Sørensen, Rikke Bæk Schrama, David Svane, Inge Marie Becker, Jürgen C. thor Straten, Per Cancer Immunol Immunother Symposium Paper Harnessing of the immune system by the development of ‘therapeutic’ vaccines, for the battle against cancer has been the focus of tremendous research efforts over the past two decades. As an illustration of the impressive amounts of data gathered over the past years, numerous antigens expressed on the surface of cancer cells, have been characterized. To this end, recent years research has focussed on characterization of antigens that play an important role for the growth and survival of cancer cells. Anti-apoptotic molecules like survivin that enhance the survival of cancer cells and facilitate their escape from cytotoxic therapies represent prime vaccination candidates. The characterization of a high number of tumor antigens allow the concurrent or serial immunological targeting of different proteins associated with such cancer traits. Moreover, while vaccination in itself is a promising new approach to fight cancer, the combination with additional therapy could create a number of synergistic effects. Herein we discuss the possibilities and prospects of vaccination when combined with other treatments. In this regard, cell death upon drug exposure may be immunogenic or non-immunogenic depending on the specific chemotherapeutics. Also, chemotherapy represents one of several options available for clearance of CD4(+) Foxp3(+) regulatory T cells. Moreover, therapies based on monoclonal antibodies may have synergistic potential in combination with vaccination, both when used for targeting of tumor cells and endothelial cells. The efficacy of therapeutic vaccination against cancer will over the next few years be studied in settings taking advantage of strategies in which vaccination is combined with other treatment modalities. These combinations should be based on current knowledge not only regarding the biology of the cancer cell per se, but also considering how treatment may influence the malignant cell population as well as the immune system. Springer-Verlag 2008-02-20 2008 /pmc/articles/PMC2522294/ /pubmed/18286284 http://dx.doi.org/10.1007/s00262-008-0480-y Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Symposium Paper
Andersen, Mads Hald
Sørensen, Rikke Bæk
Schrama, David
Svane, Inge Marie
Becker, Jürgen C.
thor Straten, Per
Cancer treatment: the combination of vaccination with other therapies
title Cancer treatment: the combination of vaccination with other therapies
title_full Cancer treatment: the combination of vaccination with other therapies
title_fullStr Cancer treatment: the combination of vaccination with other therapies
title_full_unstemmed Cancer treatment: the combination of vaccination with other therapies
title_short Cancer treatment: the combination of vaccination with other therapies
title_sort cancer treatment: the combination of vaccination with other therapies
topic Symposium Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522294/
https://www.ncbi.nlm.nih.gov/pubmed/18286284
http://dx.doi.org/10.1007/s00262-008-0480-y
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