Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

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The Sigirr gene (also known as Tir8) encodes for an orphan receptor of the Toll-like receptor (TLR)/interleukin 1 receptor family that inhibits TLR-mediated pathogen recognition in dendritic cells. Here, we show that Sigirr also inhibits the activation of dendritic cells and B cells upon exposure to...

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Detalles Bibliográficos
Autores principales: Lech, Maciej, Kulkarni, Onkar P., Pfeiffer, Stephanie, Savarese, Emina, Krug, Anne, Garlanda, Cecilia, Mantovani, Alberto, Anders, Hans-Joachim
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525585/
https://www.ncbi.nlm.nih.gov/pubmed/18644972
http://dx.doi.org/10.1084/jem.20072646

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