A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6...

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Detalles Bibliográficos
Autores principales: Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V., Benn, Caroline L., Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A., Hayden, Michael R., Khalili-Shirazi, Azadeh, Lowdell, Mark W., Brundin, Patrik, Bates, Gillian P., Leavitt, Blair R., Möller, Thomas, Tabrizi, Sarah J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525598/
https://www.ncbi.nlm.nih.gov/pubmed/18625748
http://dx.doi.org/10.1084/jem.20080178

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