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Structural similarity of genetically interacting proteins
BACKGROUND: The study of gene mutants and their interactions is fundamental to understanding gene function and backup mechanisms within the cell. The recent availability of large scale genetic interaction networks in yeast and worm allows the investigation of the biological mechanisms underlying the...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525628/ https://www.ncbi.nlm.nih.gov/pubmed/18671848 http://dx.doi.org/10.1186/1752-0509-2-69 |
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author | Dror, Oranit Schneidman-Duhovny, Dina Shulman-Peleg, Alexandra Nussinov, Ruth Wolfson, Haim J Sharan, Roded |
author_facet | Dror, Oranit Schneidman-Duhovny, Dina Shulman-Peleg, Alexandra Nussinov, Ruth Wolfson, Haim J Sharan, Roded |
author_sort | Dror, Oranit |
collection | PubMed |
description | BACKGROUND: The study of gene mutants and their interactions is fundamental to understanding gene function and backup mechanisms within the cell. The recent availability of large scale genetic interaction networks in yeast and worm allows the investigation of the biological mechanisms underlying these interactions at a global scale. To date, less than 2% of the known genetic interactions in yeast or worm can be accounted for by sequence similarity. RESULTS: Here, we perform a genome-scale structural comparison among protein pairs in the two species. We show that significant fractions of genetic interactions involve structurally similar proteins, spanning 7–10% and 14% of all known interactions in yeast and worm, respectively. We identify several structural features that are predictive of genetic interactions and show their superiority over sequence-based features. CONCLUSION: Structural similarity is an important property that can explain and predict genetic interactions. According to the available data, the most abundant mechanism for genetic interactions among structurally similar proteins is a common interacting partner shared by two genetically interacting proteins. |
format | Text |
id | pubmed-2525628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25256282008-08-27 Structural similarity of genetically interacting proteins Dror, Oranit Schneidman-Duhovny, Dina Shulman-Peleg, Alexandra Nussinov, Ruth Wolfson, Haim J Sharan, Roded BMC Syst Biol Research Article BACKGROUND: The study of gene mutants and their interactions is fundamental to understanding gene function and backup mechanisms within the cell. The recent availability of large scale genetic interaction networks in yeast and worm allows the investigation of the biological mechanisms underlying these interactions at a global scale. To date, less than 2% of the known genetic interactions in yeast or worm can be accounted for by sequence similarity. RESULTS: Here, we perform a genome-scale structural comparison among protein pairs in the two species. We show that significant fractions of genetic interactions involve structurally similar proteins, spanning 7–10% and 14% of all known interactions in yeast and worm, respectively. We identify several structural features that are predictive of genetic interactions and show their superiority over sequence-based features. CONCLUSION: Structural similarity is an important property that can explain and predict genetic interactions. According to the available data, the most abundant mechanism for genetic interactions among structurally similar proteins is a common interacting partner shared by two genetically interacting proteins. BioMed Central 2008-07-31 /pmc/articles/PMC2525628/ /pubmed/18671848 http://dx.doi.org/10.1186/1752-0509-2-69 Text en Copyright © 2008 Dror et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dror, Oranit Schneidman-Duhovny, Dina Shulman-Peleg, Alexandra Nussinov, Ruth Wolfson, Haim J Sharan, Roded Structural similarity of genetically interacting proteins |
title | Structural similarity of genetically interacting proteins |
title_full | Structural similarity of genetically interacting proteins |
title_fullStr | Structural similarity of genetically interacting proteins |
title_full_unstemmed | Structural similarity of genetically interacting proteins |
title_short | Structural similarity of genetically interacting proteins |
title_sort | structural similarity of genetically interacting proteins |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525628/ https://www.ncbi.nlm.nih.gov/pubmed/18671848 http://dx.doi.org/10.1186/1752-0509-2-69 |
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