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An Enzymatic Atavist Revealed in Dual Pathways for Water Activation

Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the biosynthesis of guanine nucleotides. This reaction involves two different chemical transformations, an NAD-linked redox reaction and a hydrolase reaction, that utilize mutually exclusive protein conformations with distinc...

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Detalles Bibliográficos
Autores principales:	Min, Donghong, Josephine, Helen R, Li, Hongzhi, Lakner, Clemens, MacPherson, Iain S, Naylor, Gavin J. P, Swofford, David, Hedstrom, Lizbeth, Yang, Wei
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525682/ https://www.ncbi.nlm.nih.gov/pubmed/18752347 http://dx.doi.org/10.1371/journal.pbio.0060206

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