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Human Aging Magnifies Genetic Effects on Executive Functioning and Working Memory

We demonstrate that common genetic polymorphisms contribute to the increasing heterogeneity of cognitive functioning in old age. We assess two common Val/Met polymorphisms, one affecting the Catechol-O-Methyltransferase (COMT) enzyme, which degrades dopamine (DA) in prefrontal cortex (PFC), and the...

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Detalles Bibliográficos
Autores principales:	Nagel, Irene E., Chicherio, Christian, Li, Shu-Chen, von Oertzen, Timo, Sander, Thomas, Villringer, Arno, Heekeren, Hauke R., Bäckman, Lars, Lindenberger, Ulman
Formato:	Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2008
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525971/ https://www.ncbi.nlm.nih.gov/pubmed/18958202 http://dx.doi.org/10.3389/neuro.09.001.2008

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