E-I Balance and Human Diseases – from Molecules to Networking

Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishme...

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Detalles Bibliográficos
Autores principales: Eichler, Sabrina A., Meier, Jochen C.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2008
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526001/
https://www.ncbi.nlm.nih.gov/pubmed/18946535
http://dx.doi.org/10.3389/neuro.02.002.2008
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author Eichler, Sabrina A.
Meier, Jochen C.
author_facet Eichler, Sabrina A.
Meier, Jochen C.
author_sort Eichler, Sabrina A.
collection PubMed
description Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.
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spelling pubmed-25260012008-10-22 E-I Balance and Human Diseases – from Molecules to Networking Eichler, Sabrina A. Meier, Jochen C. Front Mol Neurosci Neuroscience Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation. Frontiers Research Foundation 2008-03-28 /pmc/articles/PMC2526001/ /pubmed/18946535 http://dx.doi.org/10.3389/neuro.02.002.2008 Text en Copyright © 2008 Eichler and Meier. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Eichler, Sabrina A.
Meier, Jochen C.
E-I Balance and Human Diseases – from Molecules to Networking
title E-I Balance and Human Diseases – from Molecules to Networking
title_full E-I Balance and Human Diseases – from Molecules to Networking
title_fullStr E-I Balance and Human Diseases – from Molecules to Networking
title_full_unstemmed E-I Balance and Human Diseases – from Molecules to Networking
title_short E-I Balance and Human Diseases – from Molecules to Networking
title_sort e-i balance and human diseases – from molecules to networking
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526001/
https://www.ncbi.nlm.nih.gov/pubmed/18946535
http://dx.doi.org/10.3389/neuro.02.002.2008
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