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Machine learning based analyses on metabolic networks supports high-throughput knockout screens
BACKGROUND: Computational identification of new drug targets is a major goal of pharmaceutical bioinformatics. RESULTS: This paper presents a machine learning strategy to study and validate essential enzymes of a metabolic network. Each single enzyme was characterized by its local network topology,...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526078/ https://www.ncbi.nlm.nih.gov/pubmed/18652654 http://dx.doi.org/10.1186/1752-0509-2-67 |