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Dicer-dependent microRNA pathway safeguards regulatory T cell function
Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell–mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526195/ https://www.ncbi.nlm.nih.gov/pubmed/18725526 http://dx.doi.org/10.1084/jem.20081062 |
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author | Liston, Adrian Lu, Li-Fan O'Carroll, Donal Tarakhovsky, Alexander Rudensky, Alexander Y. |
author_facet | Liston, Adrian Lu, Li-Fan O'Carroll, Donal Tarakhovsky, Alexander Rudensky, Alexander Y. |
author_sort | Liston, Adrian |
collection | PubMed |
description | Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell–mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell–deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions. |
format | Text |
id | pubmed-2526195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25261952009-03-01 Dicer-dependent microRNA pathway safeguards regulatory T cell function Liston, Adrian Lu, Li-Fan O'Carroll, Donal Tarakhovsky, Alexander Rudensky, Alexander Y. J Exp Med Articles Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell–mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell–deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions. The Rockefeller University Press 2008-09-01 /pmc/articles/PMC2526195/ /pubmed/18725526 http://dx.doi.org/10.1084/jem.20081062 Text en © 2008 Liston et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Articles Liston, Adrian Lu, Li-Fan O'Carroll, Donal Tarakhovsky, Alexander Rudensky, Alexander Y. Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title | Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title_full | Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title_fullStr | Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title_full_unstemmed | Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title_short | Dicer-dependent microRNA pathway safeguards regulatory T cell function |
title_sort | dicer-dependent microrna pathway safeguards regulatory t cell function |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526195/ https://www.ncbi.nlm.nih.gov/pubmed/18725526 http://dx.doi.org/10.1084/jem.20081062 |
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