Cargando…

The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement

A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages...

Descripción completa

Detalles Bibliográficos
Autores principales: Ricker, Alyssa, Liu-Snyder, Peishan, Webster, Thomas J
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526357/
https://www.ncbi.nlm.nih.gov/pubmed/18488423
_version_ 1782158738239520768
author Ricker, Alyssa
Liu-Snyder, Peishan
Webster, Thomas J
author_facet Ricker, Alyssa
Liu-Snyder, Peishan
Webster, Thomas J
author_sort Ricker, Alyssa
collection PubMed
description A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO(4) reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO(4) compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO(4) should be further studied for improving properties of PMMA for orthopedic applications.
format Text
id pubmed-2526357
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-25263572008-09-04 The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement Ricker, Alyssa Liu-Snyder, Peishan Webster, Thomas J Int J Nanomedicine Short Communication A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO(4) reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO(4) compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO(4) should be further studied for improving properties of PMMA for orthopedic applications. Dove Medical Press 2008-03 2008-03 /pmc/articles/PMC2526357/ /pubmed/18488423 Text en © 2008 Ricker et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Short Communication
Ricker, Alyssa
Liu-Snyder, Peishan
Webster, Thomas J
The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title_full The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title_fullStr The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title_full_unstemmed The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title_short The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
title_sort influence of nano mgo and baso(4) particle size additives on properties of pmma bone cement
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526357/
https://www.ncbi.nlm.nih.gov/pubmed/18488423
work_keys_str_mv AT rickeralyssa theinfluenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement
AT liusnyderpeishan theinfluenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement
AT websterthomasj theinfluenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement
AT rickeralyssa influenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement
AT liusnyderpeishan influenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement
AT websterthomasj influenceofnanomgoandbaso4particlesizeadditivesonpropertiesofpmmabonecement