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The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement
A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526357/ https://www.ncbi.nlm.nih.gov/pubmed/18488423 |
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author | Ricker, Alyssa Liu-Snyder, Peishan Webster, Thomas J |
author_facet | Ricker, Alyssa Liu-Snyder, Peishan Webster, Thomas J |
author_sort | Ricker, Alyssa |
collection | PubMed |
description | A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO(4) reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO(4) compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO(4) should be further studied for improving properties of PMMA for orthopedic applications. |
format | Text |
id | pubmed-2526357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25263572008-09-04 The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement Ricker, Alyssa Liu-Snyder, Peishan Webster, Thomas J Int J Nanomedicine Short Communication A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO(4) reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO(4) compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO(4) should be further studied for improving properties of PMMA for orthopedic applications. Dove Medical Press 2008-03 2008-03 /pmc/articles/PMC2526357/ /pubmed/18488423 Text en © 2008 Ricker et al, publisher and licensee Dove Medical Press Ltd. |
spellingShingle | Short Communication Ricker, Alyssa Liu-Snyder, Peishan Webster, Thomas J The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title | The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title_full | The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title_fullStr | The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title_full_unstemmed | The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title_short | The influence of nano MgO and BaSO(4) particle size additives on properties of PMMA bone cement |
title_sort | influence of nano mgo and baso(4) particle size additives on properties of pmma bone cement |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526357/ https://www.ncbi.nlm.nih.gov/pubmed/18488423 |
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