Cargando…

Strategies for molecular imaging dementia and neurodegenerative diseases

Dementia represents a heterogeneous term that has evolved to describe the behavioral syndromes associated with a variety of clinical and neuropathological changes during continuing degenerative disease of the brain. As such, there lacks a clear consensus regarding the neuropsychological and other co...

Descripción completa

Detalles Bibliográficos
Autor principal: Schaller, Bernhard J
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526366/
https://www.ncbi.nlm.nih.gov/pubmed/18830391
_version_ 1782158740359741440
author Schaller, Bernhard J
author_facet Schaller, Bernhard J
author_sort Schaller, Bernhard J
collection PubMed
description Dementia represents a heterogeneous term that has evolved to describe the behavioral syndromes associated with a variety of clinical and neuropathological changes during continuing degenerative disease of the brain. As such, there lacks a clear consensus regarding the neuropsychological and other constituent characteristics associated with various cerebrovascular changes in this disease process. But increasing this knowledge has given more insights into memory deterioration in patients suffering from Alzheimer’s disease and other subtypes of dementia. The author reviews current knowledge of the physiological coupling between cerebral blood flow and metabolism in the light of state-of-the-art-imaging methods and its changes in dementia with special reference to Alzheimer’s disease. Different imaging techniques are discussed with respect to their visualizing effect of biochemical, cellular, and/or structural changes in dementia. The pathophysiology of dementia in advanced age is becoming increasingly understood by revealing the underlying basis of neuropsychological changes with current imaging techniques, genetic and pathological features, which suggests that alterations of (neuro) vascular regulatory mechanisms may lead to brain dysfunction and disease. The current view is that cerebrovascular deregulation is seen as a contributor to cerebrovascular pathologies, such as stroke, but also to neurodegenerative conditions, such as Alzheimer’s disease. The better understanding of these (patho) physiological mechanisms may open an approach to new interventional strategies in dementia to enhance neurovascular repair and to protect neurovascular coupling.
format Text
id pubmed-2526366
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-25263662008-10-01 Strategies for molecular imaging dementia and neurodegenerative diseases Schaller, Bernhard J Neuropsychiatr Dis Treat Review Dementia represents a heterogeneous term that has evolved to describe the behavioral syndromes associated with a variety of clinical and neuropathological changes during continuing degenerative disease of the brain. As such, there lacks a clear consensus regarding the neuropsychological and other constituent characteristics associated with various cerebrovascular changes in this disease process. But increasing this knowledge has given more insights into memory deterioration in patients suffering from Alzheimer’s disease and other subtypes of dementia. The author reviews current knowledge of the physiological coupling between cerebral blood flow and metabolism in the light of state-of-the-art-imaging methods and its changes in dementia with special reference to Alzheimer’s disease. Different imaging techniques are discussed with respect to their visualizing effect of biochemical, cellular, and/or structural changes in dementia. The pathophysiology of dementia in advanced age is becoming increasingly understood by revealing the underlying basis of neuropsychological changes with current imaging techniques, genetic and pathological features, which suggests that alterations of (neuro) vascular regulatory mechanisms may lead to brain dysfunction and disease. The current view is that cerebrovascular deregulation is seen as a contributor to cerebrovascular pathologies, such as stroke, but also to neurodegenerative conditions, such as Alzheimer’s disease. The better understanding of these (patho) physiological mechanisms may open an approach to new interventional strategies in dementia to enhance neurovascular repair and to protect neurovascular coupling. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2526366/ /pubmed/18830391 Text en © 2008 Schaller, publisher and licensee Dove Medical Press Ltd.
spellingShingle Review
Schaller, Bernhard J
Strategies for molecular imaging dementia and neurodegenerative diseases
title Strategies for molecular imaging dementia and neurodegenerative diseases
title_full Strategies for molecular imaging dementia and neurodegenerative diseases
title_fullStr Strategies for molecular imaging dementia and neurodegenerative diseases
title_full_unstemmed Strategies for molecular imaging dementia and neurodegenerative diseases
title_short Strategies for molecular imaging dementia and neurodegenerative diseases
title_sort strategies for molecular imaging dementia and neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526366/
https://www.ncbi.nlm.nih.gov/pubmed/18830391
work_keys_str_mv AT schallerbernhardj strategiesformolecularimagingdementiaandneurodegenerativediseases