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Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease
The aims of this study were to determine the occurrence and variables associated with the initial intravenous immunoglobulin (IVIG) treatment failure in Kawasaki disease (KD) and to categorize differences in clinical characteristics between responders and nonresponders to initial IVIG treatment. Pat...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526401/ https://www.ncbi.nlm.nih.gov/pubmed/18756064 http://dx.doi.org/10.3346/jkms.2008.23.4.718 |
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author | Cha, Sungho Yoon, Minjeong Ahn, Yongjoo Han, Miyoung Yoon, Kyung-Lim |
author_facet | Cha, Sungho Yoon, Minjeong Ahn, Yongjoo Han, Miyoung Yoon, Kyung-Lim |
author_sort | Cha, Sungho |
collection | PubMed |
description | The aims of this study were to determine the occurrence and variables associated with the initial intravenous immunoglobulin (IVIG) treatment failure in Kawasaki disease (KD) and to categorize differences in clinical characteristics between responders and nonresponders to initial IVIG treatment. Patients were classified into two groups. Group A included 33 patients who received a single dose of IVIG treatment and responded. Group B included 18 patients who received more than two doses of IVIG due to failure of the initial treatment. The mean duration of fever after initial treatment in group B was significantly longer than it was in group A. In group B, we found that higher bilirubin, aspartate aminotransferase (AST), polymorphonuclear cells (PMN) (%), and lower platelet values at baseline were independent predictors of persistent or recurrent fever in patients with KD. Coronary artery abnormalities were found in 8 patients (44.4%) in group B and in two patients (6.1%) in group A. We found that abnormal liver function tests and a lower platelet count at baseline were possible predictors of nonresponders to IVIG in patients with KD. There is a need for a prospective study focused on baseline hepatobiliary parameters. |
format | Text |
id | pubmed-2526401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-25264012008-11-07 Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease Cha, Sungho Yoon, Minjeong Ahn, Yongjoo Han, Miyoung Yoon, Kyung-Lim J Korean Med Sci Original Article The aims of this study were to determine the occurrence and variables associated with the initial intravenous immunoglobulin (IVIG) treatment failure in Kawasaki disease (KD) and to categorize differences in clinical characteristics between responders and nonresponders to initial IVIG treatment. Patients were classified into two groups. Group A included 33 patients who received a single dose of IVIG treatment and responded. Group B included 18 patients who received more than two doses of IVIG due to failure of the initial treatment. The mean duration of fever after initial treatment in group B was significantly longer than it was in group A. In group B, we found that higher bilirubin, aspartate aminotransferase (AST), polymorphonuclear cells (PMN) (%), and lower platelet values at baseline were independent predictors of persistent or recurrent fever in patients with KD. Coronary artery abnormalities were found in 8 patients (44.4%) in group B and in two patients (6.1%) in group A. We found that abnormal liver function tests and a lower platelet count at baseline were possible predictors of nonresponders to IVIG in patients with KD. There is a need for a prospective study focused on baseline hepatobiliary parameters. The Korean Academy of Medical Sciences 2008-08 2008-08-25 /pmc/articles/PMC2526401/ /pubmed/18756064 http://dx.doi.org/10.3346/jkms.2008.23.4.718 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cha, Sungho Yoon, Minjeong Ahn, Yongjoo Han, Miyoung Yoon, Kyung-Lim Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title | Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title_full | Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title_fullStr | Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title_full_unstemmed | Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title_short | Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease |
title_sort | risk factors for failure of initial intravenous immunoglobulin treatment in kawasaki disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526401/ https://www.ncbi.nlm.nih.gov/pubmed/18756064 http://dx.doi.org/10.3346/jkms.2008.23.4.718 |
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