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Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis

Many patients are currently suffering from nickel (Ni)-induced allergic contact dermatitis (ACD). There have been few Korean studies dealing with the threshold of Ni-induced ACD and quantifying the total amount of Ni in the metal alloys. The aim of this study is to evaluate the amount of Ni leached...

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Autores principales: Kim, Yoon Young, Kim, Mi-Yeon, Park, Young Min, Kim, Hyung Ok, Koh, Cjae Sook, Lee, Hae Kwang
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526423/
https://www.ncbi.nlm.nih.gov/pubmed/18437018
http://dx.doi.org/10.3346/jkms.2008.23.2.315
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author Kim, Yoon Young
Kim, Mi-Yeon
Park, Young Min
Kim, Hyung Ok
Koh, Cjae Sook
Lee, Hae Kwang
author_facet Kim, Yoon Young
Kim, Mi-Yeon
Park, Young Min
Kim, Hyung Ok
Koh, Cjae Sook
Lee, Hae Kwang
author_sort Kim, Yoon Young
collection PubMed
description Many patients are currently suffering from nickel (Ni)-induced allergic contact dermatitis (ACD). There have been few Korean studies dealing with the threshold of Ni-induced ACD and quantifying the total amount of Ni in the metal alloys. The aim of this study is to evaluate the amount of Ni leached from metal alloys and Ni contents in metal alloys, and to estimate the threshold of Ni-induced ACD. All the earrings we examined leached below 0.5 µg/cm(2)/week, the upper limit of European Union (EU) regulation, but the other metal alloys leached a much higher amount of Ni than the limit. Likewise, all the earrings we examined contained less than 0.05% Ni (500 µg/g), the upper limit of EU regulation, but the other metal alloys exceeded this limit. Twenty Ni-sensitive subjects, who were patch-tested with various concentrations of Ni sulphate, showed positive reactions to 5% and 1% Ni sulphate, 10 subjects showed positive reactions to 0.01%, and the most sensitive subject showed reaction even to 0.0001%. The subjects in this study were more sensitive to Ni than those in the previous studies done in Europe. Taken together, strictly regulating the Ni-containing alloys that are made in Korea is needed to lower the occurrence of Ni-induced ACD.
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spelling pubmed-25264232008-11-06 Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis Kim, Yoon Young Kim, Mi-Yeon Park, Young Min Kim, Hyung Ok Koh, Cjae Sook Lee, Hae Kwang J Korean Med Sci Original Article Many patients are currently suffering from nickel (Ni)-induced allergic contact dermatitis (ACD). There have been few Korean studies dealing with the threshold of Ni-induced ACD and quantifying the total amount of Ni in the metal alloys. The aim of this study is to evaluate the amount of Ni leached from metal alloys and Ni contents in metal alloys, and to estimate the threshold of Ni-induced ACD. All the earrings we examined leached below 0.5 µg/cm(2)/week, the upper limit of European Union (EU) regulation, but the other metal alloys leached a much higher amount of Ni than the limit. Likewise, all the earrings we examined contained less than 0.05% Ni (500 µg/g), the upper limit of EU regulation, but the other metal alloys exceeded this limit. Twenty Ni-sensitive subjects, who were patch-tested with various concentrations of Ni sulphate, showed positive reactions to 5% and 1% Ni sulphate, 10 subjects showed positive reactions to 0.01%, and the most sensitive subject showed reaction even to 0.0001%. The subjects in this study were more sensitive to Ni than those in the previous studies done in Europe. Taken together, strictly regulating the Ni-containing alloys that are made in Korea is needed to lower the occurrence of Ni-induced ACD. The Korean Academy of Medical Sciences 2008-04 2008-04-20 /pmc/articles/PMC2526423/ /pubmed/18437018 http://dx.doi.org/10.3346/jkms.2008.23.2.315 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Yoon Young
Kim, Mi-Yeon
Park, Young Min
Kim, Hyung Ok
Koh, Cjae Sook
Lee, Hae Kwang
Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title_full Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title_fullStr Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title_full_unstemmed Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title_short Evaluating the Nickel Content in Metal Alloys and the Threshold for Nickel-Induced Allergic Contact Dermatitis
title_sort evaluating the nickel content in metal alloys and the threshold for nickel-induced allergic contact dermatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526423/
https://www.ncbi.nlm.nih.gov/pubmed/18437018
http://dx.doi.org/10.3346/jkms.2008.23.2.315
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