Cargando…

Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria

Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Koh, Won-Jung, Kim, Yee Hyung, Kwon, O Jung, Choi, Yong Soo, Kim, Kwhanmien, Shim, Young Mog, Kim, Jhingook
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526522/
https://www.ncbi.nlm.nih.gov/pubmed/18583873
http://dx.doi.org/10.3346/jkms.2008.23.3.397
_version_ 1782158771941801984
author Koh, Won-Jung
Kim, Yee Hyung
Kwon, O Jung
Choi, Yong Soo
Kim, Kwhanmien
Shim, Young Mog
Kim, Jhingook
author_facet Koh, Won-Jung
Kim, Yee Hyung
Kwon, O Jung
Choi, Yong Soo
Kim, Kwhanmien
Shim, Young Mog
Kim, Jhingook
author_sort Koh, Won-Jung
collection PubMed
description Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who had underwent pulmonary resection. The median age of the patients was 45 yr. Of the 23 patients, 10 had Mycobacterium avium-intracellulare complex infection, 12 had M. abscessus infection, and one had M. xenopi infection. The indications for surgery were antibiotic therapy failure (n=11), remnant cavitary lesion with high probability of relapse (n=8), and massive hemoptysis (n=4). The most common procedure was lobectomy (48%). Postoperative complications occurred in eight patients (35%), including postoperative pneumonia (n=3) and late bronchopleural fistula (n=2). Negative sputum culture conversion was achieved and maintained in all except two mortalities. Although it is associated with a relatively high complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis.
format Text
id pubmed-2526522
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-25265222008-11-07 Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria Koh, Won-Jung Kim, Yee Hyung Kwon, O Jung Choi, Yong Soo Kim, Kwhanmien Shim, Young Mog Kim, Jhingook J Korean Med Sci Original Article Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who had underwent pulmonary resection. The median age of the patients was 45 yr. Of the 23 patients, 10 had Mycobacterium avium-intracellulare complex infection, 12 had M. abscessus infection, and one had M. xenopi infection. The indications for surgery were antibiotic therapy failure (n=11), remnant cavitary lesion with high probability of relapse (n=8), and massive hemoptysis (n=4). The most common procedure was lobectomy (48%). Postoperative complications occurred in eight patients (35%), including postoperative pneumonia (n=3) and late bronchopleural fistula (n=2). Negative sputum culture conversion was achieved and maintained in all except two mortalities. Although it is associated with a relatively high complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis. The Korean Academy of Medical Sciences 2008-06 2008-06-20 /pmc/articles/PMC2526522/ /pubmed/18583873 http://dx.doi.org/10.3346/jkms.2008.23.3.397 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Koh, Won-Jung
Kim, Yee Hyung
Kwon, O Jung
Choi, Yong Soo
Kim, Kwhanmien
Shim, Young Mog
Kim, Jhingook
Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title_full Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title_fullStr Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title_full_unstemmed Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title_short Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
title_sort surgical treatment of pulmonary diseases due to nontuberculous mycobacteria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526522/
https://www.ncbi.nlm.nih.gov/pubmed/18583873
http://dx.doi.org/10.3346/jkms.2008.23.3.397
work_keys_str_mv AT kohwonjung surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT kimyeehyung surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT kwonojung surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT choiyongsoo surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT kimkwhanmien surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT shimyoungmog surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria
AT kimjhingook surgicaltreatmentofpulmonarydiseasesduetonontuberculousmycobacteria