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Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria
Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who ha...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526522/ https://www.ncbi.nlm.nih.gov/pubmed/18583873 http://dx.doi.org/10.3346/jkms.2008.23.3.397 |
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author | Koh, Won-Jung Kim, Yee Hyung Kwon, O Jung Choi, Yong Soo Kim, Kwhanmien Shim, Young Mog Kim, Jhingook |
author_facet | Koh, Won-Jung Kim, Yee Hyung Kwon, O Jung Choi, Yong Soo Kim, Kwhanmien Shim, Young Mog Kim, Jhingook |
author_sort | Koh, Won-Jung |
collection | PubMed |
description | Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who had underwent pulmonary resection. The median age of the patients was 45 yr. Of the 23 patients, 10 had Mycobacterium avium-intracellulare complex infection, 12 had M. abscessus infection, and one had M. xenopi infection. The indications for surgery were antibiotic therapy failure (n=11), remnant cavitary lesion with high probability of relapse (n=8), and massive hemoptysis (n=4). The most common procedure was lobectomy (48%). Postoperative complications occurred in eight patients (35%), including postoperative pneumonia (n=3) and late bronchopleural fistula (n=2). Negative sputum culture conversion was achieved and maintained in all except two mortalities. Although it is associated with a relatively high complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis. |
format | Text |
id | pubmed-2526522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-25265222008-11-07 Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria Koh, Won-Jung Kim, Yee Hyung Kwon, O Jung Choi, Yong Soo Kim, Kwhanmien Shim, Young Mog Kim, Jhingook J Korean Med Sci Original Article Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who had underwent pulmonary resection. The median age of the patients was 45 yr. Of the 23 patients, 10 had Mycobacterium avium-intracellulare complex infection, 12 had M. abscessus infection, and one had M. xenopi infection. The indications for surgery were antibiotic therapy failure (n=11), remnant cavitary lesion with high probability of relapse (n=8), and massive hemoptysis (n=4). The most common procedure was lobectomy (48%). Postoperative complications occurred in eight patients (35%), including postoperative pneumonia (n=3) and late bronchopleural fistula (n=2). Negative sputum culture conversion was achieved and maintained in all except two mortalities. Although it is associated with a relatively high complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis. The Korean Academy of Medical Sciences 2008-06 2008-06-20 /pmc/articles/PMC2526522/ /pubmed/18583873 http://dx.doi.org/10.3346/jkms.2008.23.3.397 Text en Copyright © 2008 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Koh, Won-Jung Kim, Yee Hyung Kwon, O Jung Choi, Yong Soo Kim, Kwhanmien Shim, Young Mog Kim, Jhingook Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title | Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title_full | Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title_fullStr | Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title_full_unstemmed | Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title_short | Surgical Treatment of Pulmonary Diseases Due to Nontuberculous Mycobacteria |
title_sort | surgical treatment of pulmonary diseases due to nontuberculous mycobacteria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526522/ https://www.ncbi.nlm.nih.gov/pubmed/18583873 http://dx.doi.org/10.3346/jkms.2008.23.3.397 |
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