Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases

BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,53...

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Autores principales: Takei, Kako, Ikeda, Shinobu, Arai, Tomio, Tanaka, Noriko, Muramatsu, Masaaki, Sawabe, Motoji
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527017/
https://www.ncbi.nlm.nih.gov/pubmed/18700950
http://dx.doi.org/10.1186/1471-2407-8-235
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author Takei, Kako
Ikeda, Shinobu
Arai, Tomio
Tanaka, Noriko
Muramatsu, Masaaki
Sawabe, Motoji
author_facet Takei, Kako
Ikeda, Shinobu
Arai, Tomio
Tanaka, Noriko
Muramatsu, Masaaki
Sawabe, Motoji
author_sort Takei, Kako
collection PubMed
description BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy cases and were registered in the Japanese single-nucleotide polymorphisms (SNPs) for geriatric research (JG-SNP) Internet database. Tumors were systematically reviewed, pathologically confirmed, and assessed in relation to LTA genotype. RESULTS: The study population consisted of 827 males and 709 females, with a mean age of 80 years. Altogether, we studied 606 subjects without cancer and 930 subjects with cancer of the stomach (n = 183), lung (n = 164), colon or rectum (n = 143), or other sites. The presence of cancer was higher in males than in females. The C804A and T495C polymorphisms were associated with cancer in males (CA + AA: CC, adjusted OR = 0.72, 95% CI = 0.53 – 0.99; TC + CC: TT, adjusted OR = 1.45, 95% CI = 1.04 – 2.02; respectively) but not in females. In males, the C804A polymorphism was associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 – 0.97), whereas the T495C polymorphism was associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 – 2.65). CONCLUSION: We found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men. Further studies in larger populations should examine this hypothesis.
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spelling pubmed-25270172008-08-29 Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases Takei, Kako Ikeda, Shinobu Arai, Tomio Tanaka, Noriko Muramatsu, Masaaki Sawabe, Motoji BMC Cancer Research Article BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy cases and were registered in the Japanese single-nucleotide polymorphisms (SNPs) for geriatric research (JG-SNP) Internet database. Tumors were systematically reviewed, pathologically confirmed, and assessed in relation to LTA genotype. RESULTS: The study population consisted of 827 males and 709 females, with a mean age of 80 years. Altogether, we studied 606 subjects without cancer and 930 subjects with cancer of the stomach (n = 183), lung (n = 164), colon or rectum (n = 143), or other sites. The presence of cancer was higher in males than in females. The C804A and T495C polymorphisms were associated with cancer in males (CA + AA: CC, adjusted OR = 0.72, 95% CI = 0.53 – 0.99; TC + CC: TT, adjusted OR = 1.45, 95% CI = 1.04 – 2.02; respectively) but not in females. In males, the C804A polymorphism was associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 – 0.97), whereas the T495C polymorphism was associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 – 2.65). CONCLUSION: We found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men. Further studies in larger populations should examine this hypothesis. BioMed Central 2008-08-13 /pmc/articles/PMC2527017/ /pubmed/18700950 http://dx.doi.org/10.1186/1471-2407-8-235 Text en Copyright © 2008 Takei et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Takei, Kako
Ikeda, Shinobu
Arai, Tomio
Tanaka, Noriko
Muramatsu, Masaaki
Sawabe, Motoji
Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title_full Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title_fullStr Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title_full_unstemmed Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title_short Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
title_sort lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527017/
https://www.ncbi.nlm.nih.gov/pubmed/18700950
http://dx.doi.org/10.1186/1471-2407-8-235
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