Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,53...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527017/ https://www.ncbi.nlm.nih.gov/pubmed/18700950 http://dx.doi.org/10.1186/1471-2407-8-235 |
_version_ | 1782158787109453824 |
---|---|
author | Takei, Kako Ikeda, Shinobu Arai, Tomio Tanaka, Noriko Muramatsu, Masaaki Sawabe, Motoji |
author_facet | Takei, Kako Ikeda, Shinobu Arai, Tomio Tanaka, Noriko Muramatsu, Masaaki Sawabe, Motoji |
author_sort | Takei, Kako |
collection | PubMed |
description | BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy cases and were registered in the Japanese single-nucleotide polymorphisms (SNPs) for geriatric research (JG-SNP) Internet database. Tumors were systematically reviewed, pathologically confirmed, and assessed in relation to LTA genotype. RESULTS: The study population consisted of 827 males and 709 females, with a mean age of 80 years. Altogether, we studied 606 subjects without cancer and 930 subjects with cancer of the stomach (n = 183), lung (n = 164), colon or rectum (n = 143), or other sites. The presence of cancer was higher in males than in females. The C804A and T495C polymorphisms were associated with cancer in males (CA + AA: CC, adjusted OR = 0.72, 95% CI = 0.53 – 0.99; TC + CC: TT, adjusted OR = 1.45, 95% CI = 1.04 – 2.02; respectively) but not in females. In males, the C804A polymorphism was associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 – 0.97), whereas the T495C polymorphism was associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 – 2.65). CONCLUSION: We found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men. Further studies in larger populations should examine this hypothesis. |
format | Text |
id | pubmed-2527017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25270172008-08-29 Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases Takei, Kako Ikeda, Shinobu Arai, Tomio Tanaka, Noriko Muramatsu, Masaaki Sawabe, Motoji BMC Cancer Research Article BACKGROUND: Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS: LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy cases and were registered in the Japanese single-nucleotide polymorphisms (SNPs) for geriatric research (JG-SNP) Internet database. Tumors were systematically reviewed, pathologically confirmed, and assessed in relation to LTA genotype. RESULTS: The study population consisted of 827 males and 709 females, with a mean age of 80 years. Altogether, we studied 606 subjects without cancer and 930 subjects with cancer of the stomach (n = 183), lung (n = 164), colon or rectum (n = 143), or other sites. The presence of cancer was higher in males than in females. The C804A and T495C polymorphisms were associated with cancer in males (CA + AA: CC, adjusted OR = 0.72, 95% CI = 0.53 – 0.99; TC + CC: TT, adjusted OR = 1.45, 95% CI = 1.04 – 2.02; respectively) but not in females. In males, the C804A polymorphism was associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 – 0.97), whereas the T495C polymorphism was associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 – 2.65). CONCLUSION: We found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men. Further studies in larger populations should examine this hypothesis. BioMed Central 2008-08-13 /pmc/articles/PMC2527017/ /pubmed/18700950 http://dx.doi.org/10.1186/1471-2407-8-235 Text en Copyright © 2008 Takei et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Takei, Kako Ikeda, Shinobu Arai, Tomio Tanaka, Noriko Muramatsu, Masaaki Sawabe, Motoji Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title | Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title_full | Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title_fullStr | Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title_full_unstemmed | Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title_short | Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
title_sort | lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527017/ https://www.ncbi.nlm.nih.gov/pubmed/18700950 http://dx.doi.org/10.1186/1471-2407-8-235 |
work_keys_str_mv | AT takeikako lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases AT ikedashinobu lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases AT araitomio lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases AT tanakanoriko lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases AT muramatsumasaaki lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases AT sawabemotoji lymphotoxinalphapolymorphismsandpresenceofcancerin1536consecutiveautopsycases |