Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures

Substitutions of individual amino acids in proteins may be under very different evolutionary restraints depending on their structural and functional roles. The Environment Specific Substitution Table (ESST) describes the pattern of substitutions in terms of amino acid location within elements of sec...

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Detalles Bibliográficos
Autores principales: Gong, Sungsam, Blundell, Tom L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527532/
https://www.ncbi.nlm.nih.gov/pubmed/18833291
http://dx.doi.org/10.1371/journal.pcbi.1000179

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